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During the 16th and 17th centuries slave traders began to raid the region as part of the expansion of the Saharan and Nile River slave routes. Their captives were slaved and shipped to the Mediterranean coast, Europe, Arabia, the Western Hemisphere, or to the slave ports and factories along the West and North Africa or South the Ubanqui and Congo rivers. In the mid 19th century, the Bobangi people became major slave traders and sold their captives to the Americas using the Ubangi river to reach the coast. During the 18th century Bandia-Nzakara peoples established the Bangassou Kingdom along the Ubangi River.

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Central African Republic