Shias believe that Imamah is of the Principles of Faith (Usul al-Din).As the verse 4:165 of quran expresses the necessity to the appointment of the prophets; so after the demise of the prophet who will play the role of the prophet; till the people have not any plea against Allah.So the same logic that necessitated the assignment of prophets also is applied for Imamah.That is Allah Must assign someone similar to prophet in his attributes and Ismah as his successor to guide the people without any deviation in religion. They refer to the verse (...This day I have perfected for you your religion and completed My favor upon you and have approved for you Islam as religion...) 5:3 of Quran which was revealed to the prophet when he appointed Ali as his successor at the day of Ghadir Khumm.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): What verse in the quran expresses the necessity to the appointment of the prophets?
Ah, so.. 4:165

Most biological entities that are more complex than a virus sometimes or always carry additional genetic material besides that which resides in their chromosomes. In some contexts, such as sequencing the genome of a pathogenic microbe, "genome" is meant to include information stored on this auxiliary material, which is carried in plasmids. In such circumstances then, "genome" describes all of the genes and information on non-coding DNA that have the potential to be present.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): What is an example of an organism that has a portion of its genetic material outside of its chromosomes?
Ah, so.. pathogenic microbe

At the beginning of the Caliphate or Islamic Empire, the reliance on courts initially confined sponsorship and scholarly activities to major centres. Within several centuries, the development of Muslim educational institutions such as the madrasah and masjid eventually introduced such activities to provincial towns and dispersed them across the Islamic legal schools and Sufi orders. In addition to religious subjects, they also taught the "rational sciences," as varied as mathematics, astronomy, astrology, geography, alchemy, philosophy, magic, and occultism, depending on the curriculum of the specific institution in question. The madaris, however, were not centres of advanced scientific study; scientific advances in Islam were usually carried out by scholars working under the patronage of royal courts. During this time,[when?] the Caliphate experienced a growth in literacy, having the highest literacy rate of the Middle Ages, comparable to classical Athens' literacy in antiquity but on a much larger scale. The emergence of the maktab and madrasa institutions played a fundamental role in the relatively high literacy rates of the medieval Islamic world.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): Who disapproved of scholars to study natural sciences?
Ah, so..
unanswerable