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In the Eastern Empire the slow infiltration of the Balkans by the Slavs added a further difficulty for Justinian's successors. It began gradually, but by the late 540s Slavic tribes were in Thrace and Illyrium, and had defeated an imperial army near Adrianople in 551. In the 560s the Avars began to expand from their base on the north bank of the Danube; by the end of the 6th century they were the dominant power in Central Europe and routinely able to force the eastern emperors to pay tribute. They remained a strong power until 796. An additional problem to face the empire came as a result of the involvement of Emperor Maurice (r. 582–602) in Persian politics when he intervened in a succession dispute. This led to a period of peace, but when Maurice was overthrown, the Persians invaded and during the reign of Emperor Heraclius (r. 610–641) controlled large chunks of the empire, including Egypt, Syria, and Asia Minor, until Heraclius' successful counterattack. In 628 the empire secured a peace treaty and recovered all of its lost territories.

During the reign of what Emperor did the Persians occupy Egypt?
Heraclius