Orontid Armenia formally passed to empire of Alexander the Great following his conquest of Persia. Alexander appointed an Orontid named Mithranes to govern Armenia. Armenia later became a vassal state of the Seleucid Empire, but it maintained a considerable degree of autonomy, retaining its native rulers. Towards the end 212 BC the country was divided into two kingdoms, Greater Armenia and Armenia Sophene including Commagene or Armenia Minor. The kingdoms became so independent from Seleucid control that Antiochus III the Great waged war on them during his reign and replaced their rulers.

Orontid Armenia was given to Alexander the Great after he took control of what area?