Input: Article: With advances in medicinal chemistry, most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example, the beta-lactam antibiotics, which include the penicillins (produced by fungi in the genus Penicillium), the cephalosporins, and the carbapenems. Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials—for example, the sulfonamides, the quinolones, and the oxazolidinones—are produced solely by chemical synthesis. Many antibacterial compounds are relatively small molecules with a molecular weight of less than 2000 atomic mass units.[citation needed]

Now answer this question: How are the slufonamides,quinolones, and oxazolidinones created?

Output: synthesis

Input: Article: The 45 rpm discs also came in a variety known as extended play (EP), which achieved up to 10–15 minutes play at the expense of attenuating (and possibly compressing) the sound to reduce the width required by the groove. EP discs were cheaper to produce, and were used in cases where unit sales were likely to be more limited or to reissue LP albums on the smaller format for those people who had only 45 rpm players. LP albums could be purchased 1 EP at a time, with four items per EP, or in a boxed set with 3 EPs or 12 items. The large center hole on 45s allows for easier handling by jukebox mechanisms. EPs were generally discontinued by the late 1950s in the U.S. as three- and four-speed record players replaced the individual 45 players. One indication of the decline of the 45 rpm EP is that the last Columbia Records reissue of Frank Sinatra songs on 45 rpm EP records, called Frank Sinatra (Columbia B-2641) was issued on December 7, 1959. The EP lasted considerably longer in Europe, and was a popular format during the 1960s for recordings by artists such as Serge Gainsbourg and the Beatles.

Now answer this question: What format was phased out by the end of the 1950s?

Output: EPs

Input: Article: Several bit rates are specified in the MPEG-1 Audio Layer III standard: 32, 40, 48, 56, 64, 80, 96, 112, 128, 160, 192, 224, 256 and 320 kbit/s, with available sampling frequencies of 32, 44.1 and 48 kHz. MPEG-2 Audio Layer III allows bit rates of 8, 16, 24, 32, 40, 48, 56, 64, 80, 96, 112, 128, 144, 160 kbit/s with sampling frequencies of 16, 22.05 and 24 kHz. MPEG-2.5 Audio Layer III is restricted to bit rates of 8, 16, 24, 32, 40, 48, 56 and 64 kbit/s with sampling frequencies of 8, 11.025, and 12 kHz.[citation needed] Because of the Nyquist–Shannon sampling theorem, frequency reproduction is always strictly less than half of the sampling frequency, and imperfect filters requires a larger margin for error (noise level versus sharpness of filter), so 8 kHz sampling rate limits the maximum frequency to 4 kHz, while 48 kHz maximum sampling rate limits an MP3 to 24 kHz sound reproduction.

Now answer this question: What kind of filter requires a larger margin for error?

Output:
imperfect filters