The army's major campaign against the Indians was fought in Florida against Seminoles. It took long wars (1818–58) to finally defeat the Seminoles and move them to Oklahoma. The usual strategy in Indian wars was to seize control of the Indians winter food supply, but that was no use in Florida where there was no winter. The second strategy was to form alliances with other Indian tribes, but that too was useless because the Seminoles had destroyed all the other Indians when they entered Florida in the late eighteenth century.

What Indian tribe was the Army's major campaign against?