Avignon was the seat of the papacy from 1309 to 1376. With the return of the Pope to Rome in 1378, the Papal State developed into a major secular power, culminating in the morally corrupt papacy of Alexander VI. Florence grew to prominence amongst the Italian city-states through financial business, and the dominant Medici family became important promoters of the Renaissance through their patronage of the arts. Other city states in northern Italy also expanded their territories and consolidated their power, primarily Milan and Venice. The War of the Sicilian Vespers had by the early 14th century divided southern Italy into an Aragon Kingdom of Sicily and an Anjou Kingdom of Naples. In 1442, the two kingdoms were effectively united under Aragonese control.

What city was the seat of the papacy for most of the 14th century?