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Tobacco was one of the first major industries to develop after the Civil War. Many farmers grew some tobacco, and the invention of the cigarette made the product especially popular. Winston-Salem is the birthplace of R. J. Reynolds Tobacco Company (RJR), founded by R. J. Reynolds in 1874 as one of 16 tobacco companies in the town. By 1914 it was selling 425 million packs of Camels a year. Today it is the second-largest tobacco company in the U.S. (behind Altria Group). RJR is an indirect wholly owned subsidiary of Reynolds American Inc., which in turn is 42% owned by British American Tobacco.

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North Carolina