Problem: Tuberculosis:

TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within endosomes of alveolar macrophages. Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis. During this process, the bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell.

What do you get when you combine a lysosome and a phagosome?
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A: a phagolysosome


Problem: Federal Bureau of Investigation:

During the period from 1993 to 2011, FBI agents fired their weapons on 289 occasions; FBI internal reviews found the shots justified in all but 5 cases, in none of the 5 cases were people wounded. Samuel Walker, a professor of criminal justice at the University of Nebraska Omaha said the number of shots found to be unjustified was "suspiciously low." In the same time period, the FBI wounded 150 people, 70 of whom died; the FBI found all 150 shootings to be justified. Likewise, during the period from 2011 to the present, all shootings by FBI agents have been found to be justified by internal investigation. In a 2002 case in Maryland, an innocent man was shot, and later paid $1.3 million by the FBI after agents mistook him for a bank robber; the internal investigation found that the shooting was justified, based on the man's actions.

How often did FBI agents fire their weapons before 1993?
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A: unanswerable


Problem: Chihuahua (state):

A handful of families owned large estates (known as haciendas) and controlled the greater part of the land across the state while the vast majority of Chihuahuans were landless. The state economy was largely defined by ranching and mining. At the expense of the working class, the Díaz administration promoted economic growth by encouraging investment from foreign companies from the United Kingdom, France, Imperial Germany and the United States. The proletariat was often exploited, and found no legal protection or political recourse to redress injustices.

What was the name of the large estates owned by wealthy families?
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A: haciendas


Problem: Hellenistic period:

The Kingdom of Pontus was a Hellenistic kingdom on the southern coast of the Black Sea. It was founded by Mithridates I in 291 BC and lasted until its conquest by the Roman Republic in 63 BC. Despite being ruled by a dynasty which was a descendant of the Persian Achaemenid Empire it became hellenized due to the influence of the Greek cities on the Black Sea and its neighboring kingdoms. Pontic culture was a mix of Greek and Iranian elements, the most hellenized parts of the kingdom were on the coast, populated by Greek colonies such as Trapezus and Sinope, which became the capital of the kingdom. Epigraphic evidence also shows extensive Hellenistic influence in the interior. During the reign of Mithridates II, Pontus was allied with the Seleucids through dynastic marriages. By the time of Mithridates VI Eupator, Greek was the official language of the kingdom though Anatolian languages continued to be spoken.

Who founded the Kingdom of Pontus?
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A:
Mithridates I