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Many of the crucial events of the American Revolution—the Boston Massacre, the Boston Tea Party, Paul Revere's midnight ride, the battles of Lexington and Concord and Bunker Hill, the Siege of Boston, and many others—occurred in or near Boston. After the Revolution, Boston's long seafaring tradition helped make it one of the world's wealthiest international ports, with rum, fish, salt, and tobacco being particularly important.

Boston became one of the wealthiest international ports after what war?
Answer: the American Revolution
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The character of John's relationship with his second wife, Isabella of Angoulême, is unclear. John married Isabella whilst she was relatively young – her exact date of birth is uncertain, and estimates place her between at most 15 and more probably towards nine years old at the time of her marriage.[nb 15] Even by the standards of the time, Isabella was married whilst very young. John did not provide a great deal of money for his wife's household and did not pass on much of the revenue from her lands, to the extent that historian Nicholas Vincent has described him as being "downright mean" towards Isabella. Vincent concluded that the marriage was not a particularly "amicable" one. Other aspects of their marriage suggest a closer, more positive relationship. Chroniclers recorded that John had a "mad infatuation" with Isabella, and certainly John had conjugal relationships with Isabella between at least 1207 and 1215; they had five children. In contrast to Vincent, historian William Chester Jordan concludes that the pair were a "companionable couple" who had a successful marriage by the standards of the day.

When did John have conjugal relationships with Isabella?
Answer: 1207 and 1215
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The clearance of the pathogens, either treatment-induced or spontaneous, it can be influenced by the genetic variants carried by the individual patients. For instance, for genotype 1 hepatitis C treated with Pegylated interferon-alpha-2a or Pegylated interferon-alpha-2b (brand names Pegasys or PEG-Intron) combined with ribavirin, it has been shown that genetic polymorphisms near the human IL28B gene, encoding interferon lambda 3, are associated with significant differences in the treatment-induced clearance of the virus. This finding, originally reported in Nature, showed that genotype 1 hepatitis C patients carrying certain genetic variant alleles near the IL28B gene are more possibly to achieve sustained virological response after the treatment than others. Later report from Nature demonstrated that the same genetic variants are also associated with the natural clearance of the genotype 1 hepatitis C virus.

What is the brand name Pegasys for?
Answer:
Pegylated interferon-alpha-2b