On December 15, 2012, several news outlets reported that President Barack Obama would nominate Kerry to succeed Hillary Clinton as Secretary of State, after Susan Rice, widely seen as Obama's preferred choice, withdrew her name from consideration citing a politicized confirmation process following criticism of her response to the 2012 Benghazi attack. On December 21, Obama proposed the nomination which received positive commentary. His confirmation hearing took place on January 24, 2013, before the Senate Foreign Relations Committee, the same panel where he first testified in 1971. The committee unanimously voted to approve him on January 29, 2013, and the same day the full Senate confirmed him on a vote of 94–3. In a letter to Massachusetts Governor Deval Patrick, Kerry announced his resignation from the Senate effective February 1.

When was it reported that Kerry would become SoS?