Input: Article: De novo or "orphan" genes, whose sequence shows no similarity to existing genes, are extremely rare. Estimates of the number of de novo genes in the human genome range from 18 to 60. Such genes are typically shorter and simpler in structure than most eukaryotic genes, with few if any introns. Two primary sources of orphan protein-coding genes are gene duplication followed by extremely rapid sequence change, such that the original relationship is undetectable by sequence comparisons, and formation through mutation of "cryptic" transcription start sites that introduce a new open reading frame in a region of the genome that did not previously code for a protein.

Now answer this question: What is a gene whose sequence shows no similarity to existing genes called?

Output: De novo or "orphan" genes

Input: Article: The migration-period peoples who later coalesced into a "German" ethnicity were the Germanic tribes of the Saxons, Franci, Thuringii, Alamanni and Bavarii. These five tribes, sometimes with inclusion of the Frisians, are considered as the major groups to take part in the formation of the Germans. The varieties of the German language are still divided up into these groups. Linguists distinguish low Saxon, Franconian, Bavarian, Thuringian and Alemannic varieties in modern German. By the 9th century, the large tribes which lived on the territory of modern Germany had been united under the rule of the Frankish king Charlemagne, known in German as Karl der Große. Much of what is now Eastern Germany became Slavonic-speaking (Sorbs and Veleti), after these areas were vacated by Germanic tribes (Vandals, Lombards, Burgundians and Suebi amongst others) which had migrated into the former areas of the Roman Empire.

Now answer this question: What king united the tribes in the 9th century? 

Output: Charlemagne

Input: Article: Towards the end of the war as the role of strategic bombing became more important, a new command for the U.S. Strategic Air Forces in the Pacific was created to oversee all U.S. strategic bombing in the hemisphere, under United States Army Air Forces General Curtis LeMay. Japanese industrial production plunged as nearly half of the built-up areas of 67 cities were destroyed by B-29 firebombing raids. On 9–10 March 1945 alone, about 100,000 people were killed in a conflagration caused by an incendiary attack on Tokyo. LeMay also oversaw Operation Starvation, in which the inland waterways of Japan were extensively mined by air, which disrupted the small amount of remaining Japanese coastal sea traffic. On 26 July 1945, the President of the United States Harry S. Truman, the President of the Nationalist Government of China Chiang Kai-shek and the Prime Minister of Great Britain Winston Churchill issued the Potsdam Declaration, which outlined the terms of surrender for the Empire of Japan as agreed upon at the Potsdam Conference. This ultimatum stated that, if Japan did not surrender, it would face "prompt and utter destruction."

Now answer this question: What ultimatum stated that Japan would face "prompt and utter destruction" if it did not surrender?

Output:
Potsdam Declaration