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On 25 May 1963, the pope suffered another haemorrhage and required several blood transfusions, but the cancer had perforated the stomach wall and peritonitis soon set in. The doctors conferred in a decision regarding this matter and John XXIII's aide Loris F. Capovilla broke the news to him saying that the cancer had done its work and nothing could be done for him. Around this time, his remaining siblings arrived to be with him. By 31 May, it had become clear that the cancer had overcome the resistance of John XXIII – it had left him confined to his bed.

When was it clear that the cancer had overcome the resistance of John XXIII?
31 May