Input: Read this: By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.
Question: In what year was Primatene Mist no longer sold in the United States?

Output: 2011


QUES: Nigeria is home to a substantial network of organised crime, active especially in drug trafficking. Nigerian criminal groups are heavily involved in drug trafficking, shipping heroin from Asian countries to Europe and America; and cocaine from South America to Europe and South Africa. . The various Nigerian Confraternities or "campus cults" are active in both organised crime and in political violence as well as providing a network of corruption within Nigeria. As confraternities have extensive connections with political and military figures, they offer excellent alumni networking opportunities. The Supreme Vikings Confraternity, for example, boasts that twelve members of the Rivers State House of Assembly are cult members. On lower levels of society, there are the "area boys", organised gangs mostly active in Lagos who specialise in mugging and small-scale drug dealing. According to official statistics, gang violence in Lagos resulted in 273 civilians and 84 policemen killed in the period of August 2000 to May 2001.

How many police were killed in Lagos in Aug 2000-May 2001?
What is the answer?
ANS: 84


QUES: An advantage of the universal motor is that AC supplies may be used on motors which have some characteristics more common in DC motors, specifically high starting torque and very compact design if high running speeds are used. The negative aspect is the maintenance and short life problems caused by the commutator. Such motors are used in devices such as food mixers and power tools which are used only intermittently, and often have high starting-torque demands. Multiple taps on the field coil provide (imprecise) stepped speed control. Household blenders that advertise many speeds frequently combine a field coil with several taps and a diode that can be inserted in series with the motor (causing the motor to run on half-wave rectified AC). Universal motors also lend themselves to electronic speed control and, as such, are an ideal choice for devices like domestic washing machines. The motor can be used to agitate the drum (both forwards and in reverse) by switching the field winding with respect to the armature.
What component of a universal motor is most likely to not fail?

ANS: unanswerable


According to the scriptures, soon after the parinirvāṇa (from Sanskrit: "highest extinguishment") of Gautama Buddha, the first Buddhist council was held. As with any ancient Indian tradition, transmission of teaching was done orally. The primary purpose of the assembly was to collectively recite the teachings to ensure that no errors occurred in oral transmission. In the first council, Ānanda, a cousin of the Buddha and his personal attendant, was called upon to recite the discourses (sūtras, Pāli suttas) of the Buddha, and, according to some sources, the abhidhamma. Upāli, another disciple, recited the monastic rules (vinaya). Most scholars regard the traditional accounts of the council as greatly exaggerated if not entirely fictitious.[note 36]Richard Gombrich noted Sariputta led communal recitations of the Buddha's teaching for preservation in the Buddha's lifetime in Sangiti Sutta (Digha Nikaya #33), and something similar to the First Council must have taken place to compose Buddhist scriptures.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): Who was cousin of the Buddha?
Ah, so.. Ānanda


Question: In 1671, Robert Boyle discovered and described the reaction between iron filings and dilute acids, which results in the production of hydrogen gas. In 1766, Henry Cavendish was the first to recognize hydrogen gas as a discrete substance, by naming the gas from a metal-acid reaction "flammable air". He speculated that "flammable air" was in fact identical to the hypothetical substance called "phlogiston" and further finding in 1781 that the gas produces water when burned. He is usually given credit for its discovery as an element. In 1783, Antoine Lavoisier gave the element the name hydrogen (from the Greek ὑδρο- hydro meaning "water" and -γενής genes meaning "creator") when he and Laplace reproduced Cavendish's finding that water is produced when hydrogen is burned.
Try to answer this question if possible: Who discovered Hydrogen gas?
Answer: Robert Boyle


Input: Read this: While highly effective, the requirement for injection limited the use of norepinephrine[clarification needed] and orally active derivatives were sought. A structurally similar compound, ephedrine, was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Following the work of Henry Dale and George Barger at Burroughs-Wellcome, academic chemist Gordon Alles synthesized amphetamine and tested it in asthma patients in 1929. The drug proved to have only modest anti-asthma effects, but produced sensations of exhilaration and palpitations. Amphetamine was developed by Smith, Kline and French as a nasal decongestant under the trade name Benzedrine Inhaler. Amphetamine was eventually developed for the treatment of narcolepsy, post-encepheletic parkinsonism, and mood elevation in depression and other psychiatric indications. It received approval as a New and Nonofficial Remedy from the American Medical Association for these uses in 1937 and remained in common use for depression until the development of tricyclic antidepressants in the 1960s.
Question: When were tricyclic antidepressants developed?

Output:
1960s