Input: Gene
Genes are regulated so that they are expressed only when the product is needed, since expression draws on limited resources.:7 A cell regulates its gene expression depending on its external environment (e.g. available nutrients, temperature and other stresses), its internal environment (e.g. cell division cycle, metabolism, infection status), and its specific role if in a multicellular organism. Gene expression can be regulated at any step: from transcriptional initiation, to RNA processing, to post-translational modification of the protein. The regulation of lactose metabolism genes in E. coli (lac operon) was the first such mechanism to be described in 1961.

What example of post-translational modification of a protein was first described in 1961?
Output: The regulation of lactose metabolism genes in E. coli


Input: Article: Mali (i/ˈmɑːli/; French: [maˈli]), officially the Republic of Mali (French: République du Mali), is a landlocked country in West Africa. Mali is the eighth-largest country in Africa, with an area of just over 1,240,000 square kilometres (480,000 sq mi). The population of Mali is 14.5 million. Its capital is Bamako. Mali consists of eight regions and its borders on the north reach deep into the middle of the Sahara Desert, while the country's southern part, where the majority of inhabitants live, features the Niger and Senegal rivers. The country's economy centers on agriculture and fishing. Some of Mali's prominent natural resources include gold, being the third largest producer of gold in the African continent, and salt. About half the population lives below the international poverty line of $1.25 (U.S.) a day. A majority of the population (55%) are non-denominational Muslims.

Now answer this question: What are two major rivers located inside of Mali?

Output: Niger and Senegal rivers


Article: The onset of symptoms in myocardial infarction (MI) is usually gradual, over several minutes, and rarely instantaneous. Chest pain is the most common symptom of acute MI and is often described as a sensation of tightness, pressure, or squeezing. Chest pain due to ischemia (a lack of blood and hence oxygen supply) of the heart muscle is termed angina pectoris. Pain radiates most often to the left arm, but may also radiate to the lower jaw, neck, right arm, back, and upper abdomen, where it may mimic heartburn. Levine's sign, in which a person localizes the chest pain by clenching their fists over their sternum, has classically been thought to be predictive of cardiac chest pain, although a prospective observational study showed it had a poor positive predictive value.

Question: What does ischemia refer too?
Ans: a lack of blood


Here is a question about this article: In France the Cathars grew to represent a popular mass movement and the belief was spreading to other areas. The Cathar Crusade was initiated by the Roman Catholic Church to eliminate the Cathar heresy in Languedoc. Heresy was a major justification for the Inquisition (Inquisitio Haereticae Pravitatis, Inquiry on Heretical Perversity) and for the European wars of religion associated with the Protestant Reformation.
What is the answer to this question: What was started by the Roman Catholic Church to dispense of the Cathars in Languedoc?
****
So... The Cathar Crusade


The problem: Answer a question about this article:
In the mid 1970s, various American groups (some with ties to Downtown Manhattan's punk scene, including Television and Suicide) had begun expanding on the vocabulary of punk music. Midwestern groups such as Pere Ubu and Devo drew inspiration from the region's derelict industrial environments, employing conceptual art techniques, musique concrète and unconventional verbal styles that would presage the post-punk movement by several years. A variety of subsequent groups, including New York-based Talking Heads and Boston-based Mission of Burma, combined elements of punk with art school sensibilities. In 1978, the former band began a series of collaborations with British ambient pioneer and ex-Roxy Music member Brian Eno, experimenting with Dada-influenced lyrical techniques, dance music, and African polyrhythms. San Francisco's vibrant post-punk scene was centered around such groups as Chrome, the Residents and Tuxedomoon, who incorporated multimedia experimentation, film and ideas from Antonin Artaud's Theater of Cruelty.
Where was the band Talking Heads based out of?
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The answer: New York


The problem: Answer a question about this article:
Public religion took place within a sacred precinct that had been marked out ritually by an augur. The original meaning of the Latin word templum was this sacred space, and only later referred to a building. Rome itself was an intrinsically sacred space; its ancient boundary (pomerium) had been marked by Romulus himself with oxen and plough; what lay within was the earthly home and protectorate of the gods of the state. In Rome, the central references for the establishment of an augural templum appear to have been the Via Sacra (Sacred Way) and the pomerium. Magistrates sought divine opinion of proposed official acts through an augur, who read the divine will through observations made within the templum before, during and after an act of sacrifice. Divine disapproval could arise through unfit sacrifice, errant rites (vitium) or an unacceptable plan of action. If an unfavourable sign was given, the magistrate could repeat the sacrifice until favourable signs were seen, consult with his augural colleagues, or abandon the project. Magistrates could use their right of augury (ius augurum) to adjourn and overturn the process of law, but were obliged to base their decision on the augur's observations and advice. For Cicero, himself an augur, this made the augur the most powerful authority in the Late Republic. By his time (mid 1st century BC) augury was supervised by the college of pontifices, whose powers were increasingly woven into the magistracies of the cursus honorum.
Who designated the first boundary of Rome?
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The answer:
Romulus