Input: Read this: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
Question: How many pharmaceutical drugs were approved on average since 2001?

Output: 22.9


QUES: In spring 1855, the allied British-French commanders decided to send an Anglo-French naval squadron into the Azov Sea to undermine Russian communications and supplies to besieged Sevastopol. On 12 May 1855, British-French warships entered the Kerch Strait and destroyed the coast battery of the Kamishevaya Bay. On 21 May 1855, the gunboats and armed steamers attacked the seaport of Taganrog, the most important hub near Rostov on Don. The vast amounts of food, especially bread, wheat, barley, and rye that were amassed in the city after the outbreak of war were prevented from being exported.

Where did British-French warships enter on May 12th 1855?
What is the answer?
ANS: the Kerch Strait


QUES: Though Houston is the largest city in the United States without formal zoning regulations, it has developed similarly to other Sun Belt cities because the city's land use regulations and legal covenants have played a similar role. Regulations include mandatory lot size for single-family houses and requirements that parking be available to tenants and customers. Such restrictions have had mixed results. Though some have blamed the city's low density, urban sprawl, and lack of pedestrian-friendliness on these policies, the city's land use has also been credited with having significant affordable housing, sparing Houston the worst effects of the 2008 real estate crisis. The city issued 42,697 building permits in 2008 and was ranked first in the list of healthiest housing markets for 2009.
What is the largest city in the U.S. without formal zoning?

ANS: Houston


French members of Parliament and other French politicians also organised a protest. All political parties in Parliament—UMP, Socialists, New Centre, Communists, Democratic Movement (centre) and Greens—jointly requested a pause in the National Assembly's session, which was granted, so that MPs could step outside and unfurl a banner which read "Respect for Human Rights in China". The coach containing the torch drove past the National Assembly and the assembled protesting MPs, who shouted "Freedom for Tibet!" several times as it passed.
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): Various French politicians started protests including members of what?
Ah, so.. Parliament


Question: In 1781, Immanuel Kant published the Critique of Pure Reason, one of the most influential works in the history of the philosophy of space and time. He describes time as an a priori notion that, together with other a priori notions such as space, allows us to comprehend sense experience. Kant denies that either space or time are substance, entities in themselves, or learned by experience; he holds, rather, that both are elements of a systematic framework we use to structure our experience. Spatial measurements are used to quantify how far apart objects are, and temporal measurements are used to quantitatively compare the interval between (or duration of) events. Although space and time are held to be transcendentally ideal in this sense, they are also empirically real—that is, not mere illusions.
Try to answer this question if possible: What did Kant describe time as?
Answer: a priori notion


Problem: So that the maximum number of colors can be accurately reproduced on your computer screen, each color has been given a code number, or sRGB, which tells your computer the intensity of the red, green and blue components of that color. The intensity of each component is measured on a scale of zero to 255, which means the complete list includes 16,777,216 distinct colors and shades. The sRGB number of pure red, for example, is 255, 00, 00, which means the red component is at its maximum intensity, and there is no green or blue. The sRGB number for crimson is 220, 20, 60, which means that the red is slightly less intense and therefore darker, there is some green, which leans it toward orange; and there is a larger amount of blue,which makes it slightly blue-violet.
Over what numerical scale is color measured on a computer screen?
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Answer:
zero to 255,