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Spectre (2015) is the twenty-fourth James Bond film produced by Eon Productions. It features Daniel Craig in his fourth performance as James Bond, and Christoph Waltz as Ernst Stavro Blofeld, with the film marking the character's re-introduction into the series. It was directed by Sam Mendes as his second James Bond film following Skyfall, and was written by John Logan, Neal Purvis, Robert Wade and Jez Butterworth. It is distributed by Metro-Goldwyn-Mayer and Columbia Pictures. With a budget around $245 million, it is the most expensive Bond film and one of the most expensive films ever made.

How many James Bond films has Eon Productions produced?
Answer: twenty-four
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The Flushing Remonstrance shows support for separation of church and state as early as the mid-17th century, stating their opposition to religious persecution of any sort: "The law of love, peace and liberty in the states extending to Jews, Turks and Egyptians, as they are considered sons of Adam, which is the glory of the outward state of Holland, so love, peace and liberty, extending to all in Christ Jesus, condemns hatred, war and bondage." The document was signed December 27, 1657 by a group of English citizens in America who were affronted by persecution of Quakers and the religious policies of the Governor of New Netherland, Peter Stuyvesant. Stuyvesant had formally banned all religions other than the Dutch Reformed Church from being practiced in the colony, in accordance with the laws of the Dutch Republic. The signers indicated their "desire therefore in this case not to judge lest we be judged, neither to condemn least we be condemned, but rather let every man stand or fall to his own Master." Stuyvesant fined the petitioners and threw them in prison until they recanted. However, John Bowne allowed the Quakers to meet in his home. Bowne was arrested, jailed, and sent to the Netherlands for trial; the Dutch court exonerated Bowne.

When did a group of English citizens sign a document condemning hatred, war and bondage?
Answer: December 27, 1657
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The Mantoux tuberculin skin test is often used to screen people at high risk for TB. Those who have been previously immunized may have a false-positive test result. The test may be falsely negative in those with sarcoidosis, Hodgkin's lymphoma, malnutrition, and most notably, active tuberculosis. Interferon gamma release assays (IGRAs), on a blood sample, are recommended in those who are positive to the Mantoux test. These are not affected by immunization or most environmental mycobacteria, so they generate fewer false-positive results. However, they are affected by M. szulgai, M. marinum, and M. kansasii. IGRAs may increase sensitivity when used in addition to the skin test, but may be less sensitive than the skin test when used alone.

Which test has fewer false positives: IGRAs or the Mantoux skin test?
Answer:
IGRAs