Question: Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A direct consequence within the pharmaceutical industry value chain is that major pharmaceutical multinationals tend to increasingly outsource risks related to fundamental research, which somewhat reshapes the industry ecosystem with biotechnology companies playing an increasingly important role, and overall strategies being redefined accordingly. Some approved drugs, such as those based on re-formulation of an existing active ingredient (also referred to as Line-extensions) are much less expensive to develop.
Is there an answer to this question: What happens when companies approve drugs?

Answer: unanswerable


Question: Bal-musette is a style of French music and dance that first became popular in Paris in the 1870s and 1880s; by 1880 Paris had some 150 dance halls in the working-class neighbourhoods of the city. Patrons danced the bourrée to the accompaniment of the cabrette (a bellows-blown bagpipe locally called a "musette") and often the vielle à roue (hurdy-gurdy) in the cafés and bars of the city. Parisian and Italian musicians who played the accordion adopted the style and established themselves in Auvergnat bars especially in the 19th arrondissement, and the romantic sounds of the accordion has since become one of the musical icons of the city. Paris became a major centre for jazz and still attracts jazz musicians from all around the world to its clubs and cafés.
Is there an answer to this question: in 1880, how many dance halls were in Paris?

Answer: 150


Question: An upgrade to Windows 8 known as Windows 8.1 was officially announced by Microsoft on May 14, 2013. Following a presentation devoted to the upgrade at Build 2013, a public beta version of the upgrade was released on June 26, 2013. Windows 8.1 was released to OEM hardware partners on August 27, 2013, and released publicly as a free download through Windows Store on October 17, 2013. Volume license customers and subscribers to MSDN Plus and TechNet Plus were initially unable to obtain the RTM version upon its release; a spokesperson said the policy was changed to allow Microsoft to work with OEMs "to ensure a quality experience at general availability." However, after criticism, Microsoft reversed its decision and released the RTM build on MSDN and TechNet on September 9, 2013.
Is there an answer to this question: When was Windows 9.1 introduced?

Answer: unanswerable


Question: The annual Southampton Boat Show is held in September each year, with over 600 exhibitors present. It runs for just over a week at Mayflower Park on the city's waterfront, where it has been held since 1968. The Boat Show itself is the climax of Sea City, which runs from April to September each year to celebrate Southampton's links with the sea.
Is there an answer to this question: In what month each year is the Southampton Boat Show held?

Answer:
September