Short-term memory is supported by transient patterns of neuronal communication, dependent on regions of the frontal lobe (especially dorsolateral prefrontal cortex) and the parietal lobe. Long-term memory, on the other hand, is maintained by more stable and permanent changes in neural connections widely spread throughout the brain. The hippocampus is essential (for learning new information) to the consolidation of information from short-term to long-term memory, although it does not seem to store information itself. Without the hippocampus, new memories are unable to be stored into long-term memory, as learned from patient Henry Molaison after removal of both his hippocampi, and there will be a very short attention span. Furthermore, it may be involved in changing neural connections for a period of three months or more after the initial learning.

Which part of the brain does short-term memory seem to rely on?