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Li Zicheng then led a coalition of rebel forces numbering 200,000[a] to confront Wu Sangui, the general commanding the Ming garrison at Shanhai Pass. Shanhai Pass is a pivotal pass of the Great Wall, located fifty miles northeast of Beijing, and for years its defenses kept the Manchus from directly raiding the Ming capital. Wu Sangui, caught between a rebel army twice his size and a foreign enemy he had fought for years, decided to cast his lot with the Manchus, with whom he was familiar. Wu Sangui may have been influenced by Li Zicheng's mistreatment of his family and other wealthy and cultured officials; it was said that Li also took Wu's concubine Chen Yuanyuan for himself. Wu and Dorgon allied in the name of avenging the death of the Chongzhen Emperor. Together, the two former enemies met and defeated Li Zicheng's rebel forces in battle on May 27, 1644.

Who beat Li Zicheng's army?
Answer: Wu and Dorgon
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Outside of the Netherlands and Belgium, the dialect around the German town of Kleve (South Guelderish) both historically and genetically belongs to the Dutch language. In Northeastern France, the area around Calais was historically Dutch-speaking (West Flemish) of which an estimated 20,000 daily speakers. The cities of Dunkirk, Gravelines and Bourbourg only became predominantly French-speaking by the end of the 19th century. In the countryside, until World War I, many elementary schools continued to teach in Dutch, and the Catholic Church continued to preach and teach the catechism in Flemish in many parishes.

About how many people around Calais, France speak Dutch every day?
Answer: 20,000
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The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active.

What are the four factors that determine how the body reacts to an antigen?
Answer:
person's age, antigen type, maternal factors and the area