In the mid-1950s, Frank Burnet, inspired by a suggestion made by Niels Jerne, formulated the clonal selection theory (CST) of immunity. On the basis of CST, Burnet developed a theory of how an immune response is triggered according to the self/nonself distinction: "self" constituents (constituents of the body) do not trigger destructive immune responses, while "nonself" entities (e.g., pathogens, an allograft) trigger a destructive immune response. The theory was later modified to reflect new discoveries regarding histocompatibility or the complex "two-signal" activation of T cells. The self/nonself theory of immunity and the self/nonself vocabulary have been criticized, but remain very influential.
When was clonal selection theory first proposed?
In the mid-1950s

Fresh off spending the previous year touring the world with U2 on their Vertigo Tour, West felt inspired to compose anthemic rap songs that could operate more efficiently in large arenas. To this end, West incorporated the synthesizer into his hip-hop production, utilized slower tempos, and experimented with electronic music and influenced by music of the 1980s. In addition to U2, West drew musical inspiration from arena rock bands such as The Rolling Stones and Led Zeppelin in terms of melody and chord progression. To make his next effort, the third in a planned tetralogy of education-themed studio albums, more introspective and personal in lyricism, West listened to folk and country singer-songwriters Bob Dylan and Johnny Cash in hopes of developing methods to augment his wordplay and storytelling ability.
What band did Kanye tour with for a year?
U2

London has been the setting for many works of literature. The literary centres of London have traditionally been hilly Hampstead and (since the early 20th century) Bloomsbury. Writers closely associated with the city are the diarist Samuel Pepys, noted for his eyewitness account of the Great Fire, Charles Dickens, whose representation of a foggy, snowy, grimy London of street sweepers and pickpockets has been a major influence on people's vision of early Victorian London, and Virginia Woolf, regarded as one of the foremost modernist literary figures of the 20th century.
Which author's novels painted a dismal portrait of Victorian London?
Charles Dickens