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Several lines of evidence indicate lifestyle-induced hyperinsulinemia and reduced insulin function (i.e., insulin resistance) as a decisive factor in many disease states. For example, hyperinsulinemia and insulin resistance are strongly linked to chronic inflammation, which in turn is strongly linked to a variety of adverse developments such as arterial microinjuries and clot formation (i.e., heart disease) and exaggerated cell division (i.e., cancer). Hyperinsulinemia and insulin resistance (the so-called metabolic syndrome) are characterized by a combination of abdominal obesity, elevated blood sugar, elevated blood pressure, elevated blood triglycerides, and reduced HDL cholesterol. The negative impact of hyperinsulinemia on prostaglandin PGE1/PGE2 balance may be significant.

Hyperinsulinemia has a negative effect on the levels of which important molecules in the body?
Answer: prostaglandin PGE1/PGE2
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In 1961, writer-editor Stan Lee revolutionized superhero comics by introducing superheroes designed to appeal to more all-ages readers than the predominantly child audiences of the medium. Modern Marvel's first superhero team, the titular stars of The Fantastic Four #1 (Nov. 1961), broke convention with other comic book archetypes of the time by squabbling, holding grudges both deep and petty, and eschewing anonymity or secret identities in favor of celebrity status. Subsequently, Marvel comics developed a reputation for focusing on characterization and adult issues to a greater extent than most superhero comics before them, a quality which the new generation of older readers appreciated. This applied to The Amazing Spider-Man title in particular, which turned out to be Marvel's most successful book. Its young hero suffered from self-doubt and mundane problems like any other teenager, something readers could identify with.

What was the issue date when this superhero team debuted?
Answer: Nov. 1961
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Rebetiko, initially a music associated with the lower classes, later (and especially after the population exchange between Greece and Turkey) reached greater general acceptance as the rough edges of its overt subcultural character were softened and polished, sometimes to the point of unrecognizability. It was the base of the later laïkó (song of the people). The leading performers of the genre include Apostolos Kaldaras, Grigoris Bithikotsis, Stelios Kazantzidis, George Dalaras, Haris Alexiou and Glykeria.

What music began associated with the lower classes?
Answer:
Rebetiko