The problem: Answer a question about this article:
In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
What was discovered in long term studies?
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The answer: too toxic for human use


The problem: Answer a question about this article:
The biggest change in this year's census was in racial classification. Enumerators were instructed to no longer use the "Mulatto" classification. Instead, they were given special instructions for reporting the race of interracial persons. A person with both white and black ancestry (termed "blood") was to be recorded as "Negro," no matter the fraction of that lineage (the "one-drop rule"). A person of mixed black and American Indian ancestry was also to be recorded as "Neg" (for "Negro") unless he was considered to be "predominantly" American Indian and accepted as such within the community. A person with both White and American Indian ancestry was to be recorded as an Indian, unless his American Indian ancestry was small, and he was accepted as white within the community. In all situations in which a person had White and some other racial ancestry, he was to be reported as that other race. Persons who had minority interracial ancestry were to be reported as the race of their father.
Which parent was the deciding factor for how interracial persons were recorded in this census? 
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The answer: their father


The problem: Answer a question about this article:
English Freemasonry spread to France in the 1720s, first as lodges of expatriates and exiled Jacobites, and then as distinctively French lodges which still follow the ritual of the Moderns. From France and England, Freemasonry spread to most of Continental Europe during the course of the 18th century. The Grande Loge de France formed under the Grand Mastership of the Duke of Clermont, who exercised only nominal authority. His successor, the Duke of Orléans, reconstituted the central body as the Grand Orient de France in 1773. Briefly eclipsed during the French Revolution, French Freemasonry continued to grow in the next century.
When was the central body of the Grand Orient de France reconstituted?
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The answer: 1773


The problem: Answer a question about this article:
A 2005 paper states "recent research has failed to support earlier findings that pet ownership is associated with a reduced risk of cardiovascular disease, a reduced use of general practitioner services, or any psychological or physical benefits on health for community dwelling older people. Research has, however, pointed to significantly less absenteeism from school through sickness among children who live with pets." In one study, new guardians reported a highly significant reduction in minor health problems during the first month following pet acquisition, and this effect was sustained in those with dogs through to the end of the study.
What year did a publication come out indicating having a pet does not mean lower risk of heart disease in the elderly?
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The answer:
2005