Context and question: One way of proving that a given disease is "infectious", is to satisfy Koch's postulates (first proposed by Robert Koch), which demands that the infectious agent be identified only in patients and not in healthy controls, and that patients who contract the agent also develop the disease. These postulates were first used in the discovery that Mycobacteria species cause tuberculosis. Koch's postulates can not be applied ethically for many human diseases because they require experimental infection of a healthy individual with a pathogen produced as a pure culture. Often, even clearly infectious diseases do not meet the infectious criteria. For example, Treponema pallidum, the causative spirochete of syphilis, cannot be cultured in vitro - however the organism can be cultured in rabbit testes. It is less clear that a pure culture comes from an animal source serving as host than it is when derived from microbes derived from plate culture. Epidemiology is another important tool used to study disease in a population. For infectious diseases it helps to determine if a disease outbreak is sporadic (occasional occurrence), endemic (regular cases often occurring in a region), epidemic (an unusually high number of cases in a region), or pandemic (a global epidemic).
What must an infectious agent not be identified in to satisfy the first of Koch's postulates?
Answer: unanswerable
Context and question: The top three single agent/disease killers are HIV/AIDS, TB and malaria. While the number of deaths due to nearly every disease have decreased, deaths due to HIV/AIDS have increased fourfold. Childhood diseases include pertussis, poliomyelitis, diphtheria, measles and tetanus. Children also make up a large percentage of lower respiratory and diarrheal deaths. In 2012, approximately 3.1 million people have died due to lower respiratory infections, making it the number 4 leading cause of death in the world.
What are the top three healing diseases?
Answer: unanswerable
Context and question: Possibly the first house erected within the site was that of a Sir William Blake, around 1624. The next owner was Lord Goring, who from 1633 extended Blake's house and developed much of today's garden, then known as Goring Great Garden. He did not, however, obtain the freehold interest in the mulberry garden. Unbeknown to Goring, in 1640 the document "failed to pass the Great Seal before King Charles I fled London, which it needed to do for legal execution". It was this critical omission that helped the British royal family regain the freehold under King George III.
Which king failed to execute Goring's freehold document before fleeing to London?
Answer:
King Charles I