Input: Gregorian calendar
Most Western European countries changed the start of the year to 1 January before they adopted the Gregorian calendar. For example, Scotland changed the start of the Scottish New Year to 1 January in 1600 (this means that 1599 was a short year). England, Ireland and the British colonies changed the start of the year to 1 January in 1752 (so 1751 was a short year with only 282 days) though in England the start of the tax year remained at 25 March (O.S.), 5 April (N.S.) till 1800, when it moved to 6 April. Later in 1752 in September the Gregorian calendar was introduced throughout Britain and the British colonies (see the section Adoption). These two reforms were implemented by the Calendar (New Style) Act 1750.

On what date did most European countries set the start of the new year?
Output: 1 January

Input: Dutch language
Attestations of Old Dutch sentences are extremely rare. The oldest one first recorded has been found in the Salic law. From this Frankish document written around 510 the oldest sentence has been identified as Dutch: Maltho thi afrio lito (I say to you, I free you, serf) used to free a serf. Another old fragment of Dutch is Visc flot aftar themo uuatare (A fish was swimming in the water). The oldest conserved larger Dutch text is the Utrecht baptismal vow (776-800) starting with Forsachistu diobolae [...] ec forsacho diabolae (Do you forsake the devil? [...] I forsake the devil). Probably the most famous sentence Hebban olla vogala nestas hagunnan, hinase hic enda tu, wat unbidan we nu (All birds have started making nests, except me and you, what are we waiting for), is dated around the year 1100, written by a Flemish monk in a convent in Rochester, England.

Where did the monk who wrote the most famous Old Dutch sentence live?
Output: Rochester, England

Input: Boston
Boston's colleges and universities have a significant effect on the regional economy. Boston attracts more than 350,000 college students from around the world, who contribute more than $4.8 billion annually to the city's economy. The area's schools are major employers and attract industries to the city and surrounding region. The city is home to a number of technology companies and is a hub for biotechnology, with the Milken Institute rating Boston as the top life sciences cluster in the country. Boston receives the highest absolute amount of annual funding from the National Institutes of Health of all cities in the United States.

The Milken Institute rated Boston as the top what in the country?
Output: life sciences cluster

Input: Pharmaceutical industry
Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.

How much does it cost to develop a new drug?
Output:
about 1.3 billion