The area now known as Tennessee was first inhabited by Paleo-Indians nearly 12,000 years ago. The names of the cultural groups that inhabited the area between first settlement and the time of European contact are unknown, but several distinct cultural phases have been named by archaeologists, including Archaic (8000–1000 BC), Woodland (1000 BC–1000 AD), and Mississippian (1000–1600 AD), whose chiefdoms were the cultural predecessors of the Muscogee people who inhabited the Tennessee River Valley before Cherokee migration into the river's headwaters.

How many years ago was Tennessee first inhabited by humans?