In 2005, Argentina's indigenous population (known as pueblos originarios) numbered about 600,329 (1.6% of total population); this figure includes 457,363 people who self-identified as belonging to an indigenous ethnic group and 142,966 who identified themselves as first-generation descendants of an indigenous people. The ten most populous indigenous peoples are the Mapuche (113,680 people), the Kolla (70,505), the Toba (69,452), the Guaraní (68,454), the Wichi (40,036), the Diaguita-Calchaquí (31,753), the Mocoví (15,837), the Huarpe (14,633), the Comechingón (10,863) and the Tehuelche (10,590). Minor but important peoples are the Quechua (6,739), the Charrúa (4,511), the Pilagá (4,465), the Chané (4,376), and the Chorote (2,613). The Selknam (Ona) people are now virtually extinct in its pure form. The languages of the Diaguita, Tehuelche, and Selknam nations have become extinct or virtually extinct: the Cacán language (spoken by Diaguitas) in the 18th century and the Selknam language in the 20th century; one Tehuelche language (Southern Tehuelche) is still spoken by a handful of elderly people.

What was the number of indigenous people in Argentina as of 2005?