Uniquely among major American cities, New York is divided between, and is host to the main branches of, two different US district courts: the District Court for the Southern District of New York, whose main courthouse is on Foley Square near City Hall in Manhattan and whose jurisdiction includes Manhattan and the Bronx, and the District Court for the Eastern District of New York, whose main courthouse is in Brooklyn and whose jurisdiction includes Brooklyn, Queens, and Staten Island. The US Court of Appeals for the Second Circuit and US Court of International Trade are also based in New York, also on Foley Square in Manhattan.

In what borough is the main courthouse of the District Court for the Southern District of New York located?