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In 1896, Patrick and Gilbert observed that during a prolonged period of sleep deprivation, sleepiness increases and decreases with a period of approximately 24 hours. In 1918, J.S. Szymanski showed that animals are capable of maintaining 24-hour activity patterns in the absence of external cues such as light and changes in temperature. In the early 20th century, circadian rhythms were noticed in the rhythmic feeding times of bees. Extensive experiments were done by Auguste Forel, Ingeborg Beling, and Oskar Wahl to see whether this rhythm was due to an endogenous clock.[citation needed] Ron Konopka and Seymour Benzer isolated the first clock mutant in Drosophila in the early 1970s and mapped the "period" gene, the first discovered genetic determinant of behavioral rhythmicity. Joseph Takahashi discovered the first mammalian circadian clock mutation (clockΔ19) using mice in 1994. However, recent studies show that deletion of clock does not lead to a behavioral phenotype (the animals still have normal circadian rhythms), which questions its importance in rhythm generation.
What mutation did Takahashi discover in 1994?
A: circadian clock

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Nigeria's human rights record remains poor; According to the US Department of State, the most significant human rights problems are: use of excessive force by security forces; impunity for abuses by security forces; arbitrary arrests; prolonged pretrial detention; judicial corruption and executive influence on the judiciary; rape, torture and other cruel, inhuman or degrading treatment of prisoners, detainees and suspects; harsh and life‑threatening prison and detention centre conditions; human trafficking for the purpose of prostitution and forced labour; societal violence and vigilante killings; child labour, child abuse and child sexual exploitation; female genital mutilation (FGM); domestic violence; discrimination based on sex, ethnicity, region and religion.
What are the conditions like in Nigerian prisons?
A: harsh and life‑threatening

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People with an acute coronary syndrome where no ST elevation is demonstrated (non-ST elevation ACS or NSTEACS) are treated with aspirin. Clopidogrel is added in many cases, particularly if the risk of cardiovascular events is felt to be high and early PCI is being considered. Depending on whether early PCI is planned, a factor Xa inhibitor or a potentiator of antithrombin (fondaparinux or low molecular weight heparin respectively) may be added. In very high-risk scenarios, inhibitors of the platelet glycoprotein αIIbβ3a receptor such as eptifibatide or tirofiban may be used.
Eptifibatide has what kind of molecular weight?
A: unanswerable

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The new Supreme Court of New Zealand was officially established at the beginning of 2004, although it did not come into operation until July. The High Court of New Zealand was until 1980 known as the Supreme Court. The Supreme Court has a purely appellate jurisdiction and hears appeals from the Court of Appeal of New Zealand. In some cases, an appeal may be removed directly to the Supreme Court from the High Court. For certain cases, particularly cases which commenced in the District Court, a lower court (typically the High Court or the Court of Appeal) may be the court of final jurisdiction.
What is the role of New Zealand's highest court?
A:
purely appellate