This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

[Q]: The plague struck various countries in the Middle East during the pandemic, leading to serious depopulation and permanent change in both economic and social structures. As it spread to western Europe, the disease entered the region from southern Russia also. By autumn 1347, the plague reached Alexandria in Egypt, probably through the port's trade with Constantinople, and ports on the Black Sea. During 1347, the disease travelled eastward to Gaza, and north along the eastern coast to cities in Lebanon, Syria and Palestine, including Ashkelon, Acre, Jerusalem, Sidon, Damascus, Homs, and Aleppo. In 1348–49, the disease reached Antioch. The city's residents fled to the north, most of them dying during the journey, but the infection had been spread to the people of Asia Minor.[citation needed]
[A]: What effect did the plague have on the Middle East?


[Q]: According to the UK Government's returned 2001 census information, the city of Newcastle had a population of 189,863, whereas the metropolitan borough of Newcastle had a population of around 259,000. Newcastle has a population of 282,442 according to the Office for National Statistics. The metropolitan boroughs of North Tyneside (population circa 201,000), South Tyneside (population circa 148,000) and Gateshead (population circa 201,000) are, along with Newcastle, all part of the Tyneside conurbation (population circa 880,000). The metropolitan county of Tyne and Wear, which consists of the four aforementioned boroughs as well as the City of Sunderland (population circa 275,000), had a population of around 1,076,000 and the Tyne and Wear City Region which also includes North Durham, South East Northumberland and the Tyne Valley has a population of 1,650,000. Newcastle is also home to a large student population with Newcastle and Northumbria Universities in the local area. Areas with predominant student populations include Jesmond and Heaton.
[A]: The population of Newcastle was 189,863 according to what year's census?


[Q]: Oxygen gas (O
2) can be toxic at elevated partial pressures, leading to convulsions and other health problems.[j] Oxygen toxicity usually begins to occur at partial pressures more than 50 kilopascals (kPa), equal to about 50% oxygen composition at standard pressure or 2.5 times the normal sea-level O
2 partial pressure of about 21 kPa. This is not a problem except for patients on mechanical ventilators, since gas supplied through oxygen masks in medical applications is typically composed of only 30%–50% O
2 by volume (about 30 kPa at standard pressure). (although this figure also is subject to wide variation, depending on type of mask).
[A]:
When can oxygen gas produce a toxic condition?