In 1903 Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs. The discovery was patented and licensed to Bayer pharmaceuticals, which marketed the compound under the trade name Veronal as a sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of phenobarbital at Bayer in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on the World Health Organizations list of essential medications. The 1950s and 1960s saw increased awareness of the addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers. Today, amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of epilepsy.
What is phenobarbital used for?
epilepsy

The departures of Núñez and van Gaal were hardly noticed by the fans when compared to that of Luís Figo, then club vice-captain. Figo had become a cult hero, and was considered by Catalans to be one of their own. However, Barcelona fans were distraught by Figo's decision to join arch-rivals Real Madrid, and, during subsequent visits to the Camp Nou, Figo was given an extremely hostile reception. Upon his first return, a piglet's head and a full bottle of whiskey were thrown at him from the crowd. The next three years saw the club in decline, and managers came and went. van Gaal was replaced by Llorenç Serra Ferrer who, despite an extensive investment in players in the summer of 2000, presided over a mediocre league campaign and a humiliating first-round Champions League exit, and was eventually dismissed late in the season. Long-serving coach Carles Rexach was appointed as his replacement, initially on a temporary basis, and managed to at least steer the club to the last Champions League spot on the final day of the season. Despite better form in La Liga and a good run to the semi-finals of the Champions League, Rexach was never viewed as a long-term solution and that summer Louis van Gaal returned to the club for a second spell as manager. What followed, despite another decent Champions League performance, was one of the worst La Liga campaigns in the club's history, with the team as low as 15th in February 2003. This led to van Gaal's resignation and replacement for the rest of the campaign by Radomir Antić, though a sixth-place finish was the best that he could manage. At the end of the season, Antić's short-term contract was not renewed, and club president Joan Gaspart resigned, his position having been made completely untenable by such a disastrous season on top of the club's overall decline in fortunes since he became president three years prior.
What team did favorite play Luis Figo leave Barcelona to join?
Real Madrid

At the end of 1831, Chopin received the first major endorsement from an outstanding contemporary when Robert Schumann, reviewing the Op. 2 Variations in the Allgemeine musikalische Zeitung (his first published article on music), declared: "Hats off, gentlemen! A genius." On 26 February 1832 Chopin gave a debut Paris concert at the Salle Pleyel which drew universal admiration. The critic François-Joseph Fétis wrote in the Revue et gazette musicale: "Here is a young man who ... taking no model, has found, if not a complete renewal of piano music, ... an abundance of original ideas of a kind to be found nowhere else ..." After this concert, Chopin realized that his essentially intimate keyboard technique was not optimal for large concert spaces. Later that year he was introduced to the wealthy Rothschild banking family, whose patronage also opened doors for him to other private salons (social gatherings of the aristocracy and artistic and literary elite). By the end of 1832 Chopin had established himself among the Parisian musical elite, and had earned the respect of his peers such as Hiller, Liszt, and Berlioz. He no longer depended financially upon his father, and in the winter of 1832 he began earning a handsome income from publishing his works and teaching piano to affluent students from all over Europe. This freed him from the strains of public concert-giving, which he disliked.
When did Chopin receive his first major endorsement from Robert Schumann?
1831