Article: Despite this glowing message by the Emperor, Chan writes that a year later in 1446, the Ming court cut off all relations with the Karmapa hierarchs. Until then, the court was unaware that Deshin Shekpa had died in 1415. The Ming court had believed that the representatives of the Karma Kagyu who continued to visit the Ming capital were sent by the Karmapa.

Question: What year did the Ming cut off the Karmapa hierarchs?
Ans: 1446


Here is a question about this article: The most persistent theme throughout his films is tension in parent-child relationships. Parents (often fathers) are reluctant, absent or ignorant. Peter Banning in Hook starts off in the beginning of the film as a reluctant married-to-his-work parent who through the course of the film regains the respect of his children. The notable absence of Elliott's father in E.T., is the most famous example of this theme. In Indiana Jones and the Last Crusade, it is revealed that Indy has always had a very strained relationship with his father, who is a professor of medieval literature, as his father always seemed more interested in his work, specifically in his studies of the Holy Grail, than in his own son, although his father does not seem to realize or understand the negative effect that his aloof nature had on Indy (he even believes he was a good father in the sense that he taught his son "self reliance," which is not how Indy saw it). Even Oskar Schindler, from Schindler's List, is reluctant to have a child with his wife. Munich depicts Avner as a man away from his wife and newborn daughter. There are of course exceptions; Brody in Jaws is a committed family man, while John Anderton in Minority Report is a shattered man after the disappearance of his son. This theme is arguably the most autobiographical aspect of Spielberg's films, since Spielberg himself was affected by his parents' divorce as a child and by the absence of his father. Furthermore, to this theme, protagonists in his films often come from families with divorced parents, most notably E.T. the Extra-Terrestrial (protagonist Elliot's mother is divorced) and Catch Me If You Can (Frank Abagnale's mother and father split early on in the film). Little known also is Tim in Jurassic Park (early in the film, another secondary character mentions Tim and Lex's parents' divorce). The family often shown divided is often resolved in the ending as well. Following this theme of reluctant fathers and father figures, Tim looks to Dr. Alan Grant as a father figure. Initially, Dr. Grant is reluctant to return those paternal feelings to Tim. However, by the end of the film, he has changed, and the kids even fall asleep with their heads on his shoulders.
What is the answer to this question: What artifact did Indy's father focus on?
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So... the Holy Grail


The problem: Answer a question about this article:
Due to the chemical composition of the pentose residues of the bases, DNA strands have directionality. One end of a DNA polymer contains an exposed hydroxyl group on the deoxyribose; this is known as the 3' end of the molecule. The other end contains an exposed phosphate group; this is the 5' end. The two strands of a double-helix run in opposite directions. Nucleic acid synthesis, including DNA replication and transcription occurs in the 5'→3' direction, because new nucleotides are added via a dehydration reaction that uses the exposed 3' hydroxyl as a nucleophile.:27.2
What type of synthesis occurs in the 5'→3' direction?
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The answer: Nucleic acid synthesis


Problem: Please answer a question about the following article about 2008 Sichuan earthquake:
Official figures (as of July 21, 2008 12:00 CST) stated that 69,197 were confirmed dead, including 68,636 in Sichuan province, and 374,176 injured, with 18,222 listed as missing. The earthquake left about 4.8 million people homeless, though the number could be as high as 11 million. Approximately 15 million people lived in the affected area. It was the deadliest earthquake to hit China since the 1976 Tangshan earthquake, which killed at least 240,000 people, and the strongest in the country since the 1950 Chayu earthquake, which registered at 8.5 on the Richter magnitude scale. It is the 21st deadliest earthquake of all time. On November 6, 2008, the central government announced that it would spend 1 trillion RMB (about US $146.5 billion) over the next three years to rebuild areas ravaged by the earthquake, as part of the Chinese economic stimulus program.
How many people were confirmed dead?
A: 69,197


Question: Read this and answer the question

In 1985, the combination of the Mac, Apple's LaserWriter printer, and Mac-specific software like Boston Software's MacPublisher and Aldus PageMaker enabled users to design, preview, and print page layouts complete with text and graphics—an activity to become known as desktop publishing. Initially, desktop publishing was unique to the Macintosh, but eventually became available for other platforms. Later, applications such as Macromedia FreeHand, QuarkXPress, and Adobe's Photoshop and Illustrator strengthened the Mac's position as a graphics computer and helped to expand the emerging desktop publishing market.

When was the activity of desktop publishing first used?
Answer: 1985


Swiss citizens are universally required to buy health insurance from private insurance companies, which in turn are required to accept every applicant. While the cost of the system is among the highest it compares well with other European countries in terms of health outcomes; patients who are citizens have been reported as being, in general, highly satisfied with it. In 2012, life expectancy at birth was 80.4 years for men and 84.7 years for women — the highest in the world. However, spending on health is particularly high at 11.4% of GDP (2010), on par with Germany and France (11.6%) and other European countries, and notably less than spending in the USA (17.6%). From 1990, a steady increase can be observed, reflecting the high costs of the services provided. With an ageing population and new healthcare technologies, health spending will likely continue to rise.
Who are private insurance companies required to accept?
every applicant