Buddhism first entered China during the Eastern Han and was first mentioned in 65 AD. Liu Ying (d. 71 AD), a half-brother to Emperor Ming of Han (r. 57–75 AD), was one of its earliest Chinese adherents, although Chinese Buddhism at this point was heavily associated with Huang-Lao Daoism. China's first known Buddhist temple, the White Horse Temple, was erected during Ming's reign. Important Buddhist canons were translated into Chinese during the 2nd century AD, including the Sutra of Forty-two Chapters, Perfection of Wisdom, Shurangama Sutra, and Pratyutpanna Sutra.

During was era did Buddhism first appear in the region?