Problem: Please answer a question about the following article about Circadian rhythm:
The central oscillator generates a self-sustaining rhythm and is driven by two interacting feedback loops that are active at different times of day. The morning loop consists of CCA1 (Circadian and Clock-Associated 1) and LHY (Late Elongated Hypocotyl), which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 (Pseudo-Response Regulators.) The evening loop consists of GI (Gigantea) and ELF4, both involved in regulation of flowering time genes. When CCA1 and LHY are overexpressed (under constant light or dark conditions), plants become arrhythmic, and mRNA signals reduce, contributing to a negative feedback loop. Gene expression of CCA1 and LHY oscillates and peaks in the early morning, whereas TOC1 gene expression oscillates and peaks in the early evening. While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY repress TOC1 and over-expressed TOC1 is a positive regulator of CCA1 and LHY, it was shown in 2012 by Andrew Millar and others that TOC1 in fact serves as a repressor not only of CCA1, LHY, and PRR7 and 9 in the morning loop but also of GI and ELF4 in the evening loop. This finding and further computational modeling of TOC1 gene functions and interactions suggest a reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing the clock in mammals.
What produces a self-sustaining rhythm?
A: central oscillator
Problem: Please answer a question about the following article about Alfred North Whitehead:
Whitehead and Russell had thought originally that Principia Mathematica would take a year to complete; it ended up taking them ten years. To add insult to injury, when it came time for publication, the three-volume work was so massive (more than 2,000 pages) and its audience so narrow (professional mathematicians) that it was initially published at a loss of 600 pounds, 300 of which was paid by Cambridge University Press, 200 by the Royal Society of London, and 50 apiece by Whitehead and Russell themselves. Despite the initial loss, today there is likely no major academic library in the world which does not hold a copy of Principia Mathematica.
How prevalent is Principia Mathematica today?
A: today there is likely no major academic library in the world which does not hold a copy of Principia Mathematica
Problem: Please answer a question about the following article about Modern history:
In China, urbanization increased as the population grew and as the division of labor grew more complex. Large urban centers, such as Nanjing and Beijing, also contributed to the growth of private industry. In particular, small-scale industries grew up, often specializing in paper, silk, cotton, and porcelain goods. For the most part, however, relatively small urban centers with markets proliferated around the country. Town markets mainly traded food, with some necessary manufactures such as pins or oil. Despite the xenophobia and intellectual introspection characteristic of the increasingly popular new school of neo-Confucianism, China under the early Ming dynasty was not isolated. Foreign trade and other contacts with the outside world, particularly Japan, increased considerably. Chinese merchants explored all of the Indian Ocean, reaching East Africa with the treasure voyages of Zheng He.
Under what rule was China not isolated?
A: the early Ming dynasty
Problem: Please answer a question about the following article about Bern:
The structure of Bern's city centre is largely medieval and has been recognised by UNESCO as a Cultural World Heritage Site. Perhaps its most famous sight is the Zytglogge (Bernese German for "Time Bell"), an elaborate medieval clock tower with moving puppets. It also has an impressive 15th century Gothic cathedral, the Münster, and a 15th-century town hall. Thanks to 6 kilometres (4 miles) of arcades, the old town boasts one of the longest covered shopping promenades in Europe.
What is the name of the 15th century cathedral?
A:
Münster