Problem: Circadian rhythm:

The central oscillator generates a self-sustaining rhythm and is driven by two interacting feedback loops that are active at different times of day. The morning loop consists of CCA1 (Circadian and Clock-Associated 1) and LHY (Late Elongated Hypocotyl), which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 (Pseudo-Response Regulators.) The evening loop consists of GI (Gigantea) and ELF4, both involved in regulation of flowering time genes. When CCA1 and LHY are overexpressed (under constant light or dark conditions), plants become arrhythmic, and mRNA signals reduce, contributing to a negative feedback loop. Gene expression of CCA1 and LHY oscillates and peaks in the early morning, whereas TOC1 gene expression oscillates and peaks in the early evening. While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY repress TOC1 and over-expressed TOC1 is a positive regulator of CCA1 and LHY, it was shown in 2012 by Andrew Millar and others that TOC1 in fact serves as a repressor not only of CCA1, LHY, and PRR7 and 9 in the morning loop but also of GI and ELF4 in the evening loop. This finding and further computational modeling of TOC1 gene functions and interactions suggest a reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing the clock in mammals.

What produces a self-sustaining rhythm?
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A: central oscillator


Problem: The Muslim population of the region consisted mainly of native Iberian converts to Islam (the so-called Muwallad or Muladi) and to a lesser extent Berbers and Arabs. The Arabs were principally noblemen from Oman; and though few in numbers, they constituted the elite of the population. The Berbers were originally from the Atlas mountains and Rif mountains of North Africa and were essentially nomads. In Portugal, the Muslim population (or "Moors"), relatively small in numbers, stayed in the Algarve region, and south of the Tagus. Today, there are approximately 800 words in the Portuguese language of Arabic origin. The Muslims were expelled from Portugal 300 years earlier than in neighbouring Spain, which is reflected both in Portuguese culture and the language, which is mostly Celtiberian and Vulgar Latin.
Who did the Arabs principally consist of?
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Answer: noblemen from Oman


Q: What is a question about this article? If the question is unanswerable, say "unanswerable".
UNFPA is the world's largest multilateral source of funding for population and reproductive health programs. The Fund works with governments and non-governmental organizations in over 150 countries with the support of the international community, supporting programs that help women, men and young people:
In addition to working directly with governments, with whom does UNFPA work?
A: non-governmental organizations


Context and question: The modern pharmaceutical industry traces its roots to two sources. The first of these were local apothecaries that expanded from their traditional role distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid 1800s. Rational drug discovery from plants started particularly with the isolation of morphine, analgesic and sleep-inducing agent from opium, by the German apothecary assistant Friedrich Sertürner, who named the compound after the Greek god of dreams, Morpheus. Multinational corporations including Merck, Hoffman-La Roche, Burroughs-Wellcome (now part of Glaxo Smith Kline), Abbott Laboratories, Eli Lilly and Upjohn (now part of Pfizer) began as local apothecary shops in the mid-1800s. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from coal tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis. The development of synthetic chemical methods allowed scientists to systematically vary the structure of chemical substances, and growth in the emerging science of pharmacology expanded their ability to evaluate the biological effects of these structural changes.
Who came up with the name Glaxo?
Answer: unanswerable


Question: Technological developments by videoconferencing developers in the 2010s have extended the capabilities of video conferencing systems beyond the boardroom for use with hand-held mobile devices that combine the use of video, audio and on-screen drawing capabilities broadcasting in real-time over secure networks, independent of location. Mobile collaboration systems now allow multiple people in previously unreachable locations, such as workers on an off-shore oil rig, the ability to view and discuss issues with colleagues thousands of miles away. Traditional videoconferencing system manufacturers have begun providing mobile applications as well, such as those that allow for live and still image streaming.
Is there an answer to this question: What does still image streaming allow?

Answer: unanswerable


Problem: Classical music:

Classical musicians continued to use many of instruments from the Baroque era, such as the cello, contrabass, recorder, trombone, timpani, fortepiano and organ. While some Baroque instruments fell into disuse (e.g., the theorbo and rackett), many Baroque instruments were changed into the versions that are still in use today, such as the Baroque violin (which became the violin), the Baroque oboe (which became the oboe) and the Baroque trumpet, which transitioned to the regular valved trumpet.

The Baroque violin became what modern instrument?
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A:
the violin