Context and question: Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of the genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome. Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange. For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when a resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound.
What does some resistance come from?
Answer: mutation
Context and question: The settlement of Plympton, further up the River Plym than the current Plymouth, was also an early trading port, but the river silted up in the early 11th century and forced the mariners and merchants to settle at the current day Barbican near the river mouth. At the time this village was called Sutton, meaning south town in Old English. The name Plym Mouth, meaning "mouth of the River Plym" was first mentioned in a Pipe Roll of 1211. The name Plymouth first officially replaced Sutton in a charter of King Henry VI in 1440. See Plympton for the derivation of the name Plym.
In what century were sailors obligated to relocate from Plympton due to silting?
Answer: 11th
Context and question: There are dozens of other chemical neurotransmitters that are used in more limited areas of the brain, often areas dedicated to a particular function. Serotonin, for example—the primary target of antidepressant drugs and many dietary aids—comes exclusively from a small brainstem area called the Raphe nuclei. Norepinephrine, which is involved in arousal, comes exclusively from a nearby small area called the locus coeruleus. Other neurotransmitters such as acetylcholine and dopamine have multiple sources in the brain, but are not as ubiquitously distributed as glutamate and GABA.
Which chemical of the brain is involved with arousal?
Answer:
Norepinephrine