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The Standard Output Sensitivity (SOS) technique, also new in the 2006 version of the standard, effectively specifies that the average level in the sRGB image must be 18% gray plus or minus 1/3 stop when the exposure is controlled by an automatic exposure control system calibrated per ISO 2721 and set to the EI with no exposure compensation. Because the output level is measured in the sRGB output from the camera, it is only applicable to sRGB images—typically JPEG—and not to output files in raw image format. It is not applicable when multi-zone metering is used.

With what type of metering can the Standard Output Sensitivity not be used?
multi-zone metering