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Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.

How many approvals of new drugs happen every year?
Answer: averaged 22.9 approvals
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Popular opinion remained firmly behind the celebration of Mary's conception. In 1439, the Council of Basel, which is not reckoned an ecumenical council, stated that belief in the immaculate conception of Mary is in accord with the Catholic faith. By the end of the 15th century the belief was widely professed and taught in many theological faculties, but such was the influence of the Dominicans, and the weight of the arguments of Thomas Aquinas (who had been canonised in 1323 and declared "Doctor Angelicus" of the Church in 1567) that the Council of Trent (1545–63)—which might have been expected to affirm the doctrine—instead declined to take a position.

How did the Holy Roman Church rule on the matter of the festivals ?
Answer: stated that belief in the immaculate conception of Mary is in accord with the Catholic faith.
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In absolute terms, the planet has lost 52% of its biodiversity since 1970 according to a 2014 study by the World Wildlife Fund. The Living Planet Report 2014 claims that "the number of mammals, birds, reptiles, amphibians and fish across the globe is, on average, about half the size it was 40 years ago". Of that number, 39% accounts for the terrestrial wildlife gone, 39% for the marine wildlife gone, and 76% for the freshwater wildlife gone. Biodiversity took the biggest hit in Latin America, plummeting 83 percent. High-income countries showed a 10% increase in biodiversity, which was canceled out by a loss in low-income countries. This is despite the fact that high-income countries use five times the ecological resources of low-income countries, which was explained as a result of process whereby wealthy nations are outsourcing resource depletion to poorer nations, which are suffering the greatest ecosystem losses.

What percentage of biodiversity has the planet lost since 1970
Answer:
52%