The Old Swiss Confederacy had acquired a reputation of invincibility during these earlier wars, but expansion of the federation suffered a setback in 1515 with the Swiss defeat in the Battle of Marignano. This ended the so-called "heroic" epoch of Swiss history. The success of Zwingli's Reformation in some cantons led to inter-cantonal religious conflicts in 1529 and 1531 (Wars of Kappel). It was not until more than one hundred years after these internal wars that, in 1648, under the Peace of Westphalia, European countries recognized Switzerland's independence from the Holy Roman Empire and its neutrality.

Which Battle was the first to interrupt the seeming invincibility of the Old Swiss Confederacy in 1515?