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By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.

What trade name was epinephrine marketed under?
Answer: Adrenalin
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Most of the space in the brain is taken up by axons, which are often bundled together in what are called nerve fiber tracts. A myelinated axon is wrapped in a fatty insulating sheath of myelin, which serves to greatly increase the speed of signal propagation. (There are also unmyelinated axons). Myelin is white, making parts of the brain filled exclusively with nerve fibers appear as light-colored white matter, in contrast to the darker-colored grey matter that marks areas with high densities of neuron cell bodies.

Most of the space in the brain is made up of what structures?
Answer: axons
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Studio producers Richard D. Zanuck and David Brown offered Spielberg the director's chair for Jaws, a thriller-horror film based on the Peter Benchley novel about an enormous killer shark. Spielberg has often referred to the gruelling shoot as his professional crucible. Despite the film's ultimate, enormous success, it was nearly shut down due to delays and budget over-runs. But Spielberg persevered and finished the film. It was an enormous hit, winning three Academy Awards (for editing, original score and sound) and grossing more than $470 million worldwide at the box office. It also set the domestic record for box office gross, leading to what the press described as "Jawsmania.":248 Jaws made Spielberg a household name and one of America's youngest multi-millionaires, allowing him a great deal of autonomy for his future projects.:250 It was nominated for Best Picture and featured Spielberg's first of three collaborations with actor Richard Dreyfuss.

How many Academy Awards did 'Jaws' win?
Answer:
three