Problem: Genome:

Interspersed repeats mainly come from transposable elements (TEs), but they also include some protein coding gene families and pseudogenes. Transposable elements are able to integrate into the genome at another site within the cell. It is believed that TEs are an important driving force on genome evolution of higher eukaryotes. TEs can be classified into two categories, Class 1 (retrotransposons) and Class 2 (DNA transposons).

What are pseudogenes able to do within the cell?
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A: unanswerable


Problem: To unambiguously specify the date, dual dating or Old Style (O.S.) and New Style (N.S.) are sometimes used with dates. Dual dating uses two consecutive years because of differences in the starting date of the year, or includes both the Julian and Gregorian dates. Old Style and New Style (N.S.) indicate either whether the start of the Julian year has been adjusted to start on 1 January (N.S.) even though documents written at the time use a different start of year (O.S.), or whether a date conforms to the Julian calendar (O.S.) rather than the Gregorian (N.S.).
What is used with dates to determine whether a date is correct or not?
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Answer: unanswerable


Q: What is a question about this article? If the question is unanswerable, say "unanswerable".
Alpine crystals have been studied and collected for hundreds of years, and began to be classified in the 18th century. Leonhard Euler studied the shapes of crystals, and by the 19th century crystal hunting was common in Alpine regions. David Friedrich Wiser amassed a collection of 8000 crystals that he studied and documented. In the 20th century Robert Parker wrote a well-known work about the rock crystals of the Swiss Alps; at the same period a commission was established to control and standardize the naming of Alpine minerals.
How long have Alpine crystals been studied and collected? 
A: hundreds of years


Context and question: In Lemon v. Kurtzman, 403 U.S. 602 (1971), the court determined that a Pennsylvania state policy of reimbursing the salaries and related costs of teachers of secular subjects in private religious schools violated the Establishment Clause. The court's decision argued that the separation of church and state could never be absolute: "Our prior holdings do not call for total separation between church and state; total separation is not possible in an absolute sense. Some relationship between government and religious organizations is inevitable," the court wrote. "Judicial caveats against entanglement must recognize that the line of separation, far from being a "wall," is a blurred, indistinct, and variable barrier depending on all the circumstances of a particular relationship."
 Whose salaries were being reimbursed in public religious schools?
Answer: unanswerable


Question: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
Is there an answer to this question: What does NMEs stand for?

Answer: New Molecular Entities


Problem: Comprehensive school:

Gibraltar opened its first comprehensive school in 1972. Between the ages of 12 and 16 two comprehensive schools cater for girls and boys separately. Students may also continue into the sixth form to complete their A-levels.

When was the first comprehensive school closed in Gibraltar?
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A:
unanswerable