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Antibiotics are screened for any negative effects on humans or other mammals before approval for clinical use, and are usually considered safe and most are well tolerated. However, some antibiotics have been associated with a range of adverse side effects. Side-effects range from mild to very serious depending on the antibiotics used, the microbial organisms targeted, and the individual patient. Side effects may reflect the pharmacological or toxicological properties of the antibiotic or may involve hypersensitivity reactions or anaphylaxis. Safety profiles of newer drugs are often not as well established as for those that have a long history of use. Adverse effects range from fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis. Common side-effects include diarrhea, resulting from disruption of the species composition in the intestinal flora, resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridium difficile. Antibacterials can also affect the vaginal flora, and may lead to overgrowth of yeast species of the genus Candida in the vulvo-vaginal area. Additional side-effects can result from interaction with other drugs, such as elevated risk of tendon damage from administration of a quinolone antibiotic with a systemic corticosteroid. Some scientists have hypothesized that the indiscriminate use of antibiotics alter the host microbiota and this has been associated with chronic disease.

What was altered during the hypothesis of indiscriminate use of antibiotics?
Answer: host microbiota
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Counting shipping as quasi-exports and in terms of monetary value, Greece ranked 4th globally in 2011 having "exported" shipping services worth 17,704.132 million $; only Denmark, Germany and South Korea ranked higher during that year. Similarly counting shipping services provided to Greece by other countries as quasi-imports and the difference between "exports" and "imports" as a "trade balance", Greece in 2011 ranked in the latter second behind Germany, having "imported" shipping services worth 7,076.605 million US$ and having run a "trade surplus" of 10,712.342 million US$.

What three countries were ahead of Greece in 2011 with exports?
Answer: Denmark, Germany and South Korea
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Hiberni (Ireland), Pictish (northern Britain) and Britons (southern Britain) tribes, all speaking Insular Celtic, inhabited the islands at the beginning of the 1st millennium AD. Much of Brittonic-controlled Britain was conquered by the Roman Empire from AD 43. The first Anglo-Saxons arrived as Roman power waned in the 5th century and eventually dominated the bulk of what is now England. Viking invasions began in the 9th century, followed by more permanent settlements and political change—particularly in England. The subsequent Norman conquest of England in 1066 and the later Angevin partial conquest of Ireland from 1169 led to the imposition of a new Norman ruling elite across much of Britain and parts of Ireland. By the Late Middle Ages, Great Britain was separated into the Kingdoms of England and Scotland, while control in Ireland fluxed between Gaelic kingdoms, Hiberno-Norman lords and the English-dominated Lordship of Ireland, soon restricted only to The Pale. The 1603 Union of the Crowns, Acts of Union 1707 and Acts of Union 1800 attempted to consolidate Britain and Ireland into a single political unit, the United Kingdom of Great Britain and Ireland, with the Isle of Man and the Channel Islands remaining as Crown Dependencies. The expansion of the British Empire and migrations following the Irish Famine and Highland Clearances resulted in the distribution of the islands' population and culture throughout the world and a rapid de-population of Ireland in the second half of the 19th century. Most of Ireland seceded from the United Kingdom after the Irish War of Independence and the subsequent Anglo-Irish Treaty (1919–1922), with six counties remaining in the UK as Northern Ireland.

When did the Pictish tribe start to inhabit the islands?
Answer:
beginning of the 1st millennium AD