Read this: One challenge to the traditional concept of matter as tangible "stuff" came with the rise of field physics in the 19th century. Relativity shows that matter and energy (including the spatially distributed energy of fields) are interchangeable. This enables the ontological view that energy is prima materia and matter is one of its forms. On the other hand, the Standard Model of Particle physics uses quantum field theory to describe all interactions. On this view it could be said that fields are prima materia and the energy is a property of the field.
Now answer this question, if there is an answer (If it cannot be answered, return "unanswerable"):  Quantum field theory determines what is not the main substance?
unanswerable