Problem: Circadian rhythm:

The central oscillator generates a self-sustaining rhythm and is driven by two interacting feedback loops that are active at different times of day. The morning loop consists of CCA1 (Circadian and Clock-Associated 1) and LHY (Late Elongated Hypocotyl), which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 (Pseudo-Response Regulators.) The evening loop consists of GI (Gigantea) and ELF4, both involved in regulation of flowering time genes. When CCA1 and LHY are overexpressed (under constant light or dark conditions), plants become arrhythmic, and mRNA signals reduce, contributing to a negative feedback loop. Gene expression of CCA1 and LHY oscillates and peaks in the early morning, whereas TOC1 gene expression oscillates and peaks in the early evening. While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY repress TOC1 and over-expressed TOC1 is a positive regulator of CCA1 and LHY, it was shown in 2012 by Andrew Millar and others that TOC1 in fact serves as a repressor not only of CCA1, LHY, and PRR7 and 9 in the morning loop but also of GI and ELF4 in the evening loop. This finding and further computational modeling of TOC1 gene functions and interactions suggest a reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing the clock in mammals.

What was the previous belief of feedback in the gene loop?
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A: negative feedback loop


Problem: The strides that the Johnson presidency made in ensuring equal opportunity in the workforce were further picked up by his successor Nixon. In 1969 the Nixon administration initiated the "Philadelphia Order". It was regarded as the most forceful plan thus far to guarantee fair hiring practices in construction jobs. Philadelphia was selected as the test case because, as Assistant Secretary of Labor Arthur Fletcher explained, "The craft unions and the construction industry are among the most egregious offenders against equal opportunity laws . . . openly hostile toward letting blacks into their closed circle." The order included definite "goals and timetables." As President Nixon asserted, "We would not impose quotas, but would require federal contractors to show 'affirmative action' to meet the goals of increasing minority employment."
 Which piece of legislation was ended in 1969?
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Answer: unanswerable


Q: What is a question about this article? If the question is unanswerable, say "unanswerable".
By the late Eastern Han period, an early form of semi-cursive script appeared, developing out of a cursively written form of neo-clerical script[c] and simple cursive. This semi-cursive script was traditionally attributed to Liu Desheng c. 147–188 AD,[d] although such attributions refer to early masters of a script rather than to their actual inventors, since the scripts generally evolved into being over time. Qiu gives examples of early semi-cursive script, showing that it had popular origins rather than being purely Liu’s invention.
What script was traditionally attributed to Liu Desheng?
A: semi-cursive


Context and question: Bell believed the photophone's principles were his life's "greatest achievement", telling a reporter shortly before his death that the photophone was "the greatest invention [I have] ever made, greater than the telephone". The photophone was a precursor to the fiber-optic communication systems which achieved popular worldwide usage in the 1980s. Its master patent was issued in December 1880, many decades before the photophone's principles came into popular use.
What modern technology takes the next step from the photophone?
Answer: fiber-optic communication


Question: Beginning in the late 1910s and early 1920s, Whitehead gradually turned his attention from mathematics to philosophy of science, and finally to metaphysics. He developed a comprehensive metaphysical system which radically departed from most of western philosophy. Whitehead argued that reality consists of processes rather than material objects, and that processes are best defined by their relations with other processes, thus rejecting the theory that reality is fundamentally constructed by bits of matter that exist independently of one another. Today Whitehead's philosophical works – particularly Process and Reality – are regarded as the foundational texts of process philosophy.
Is there an answer to this question: After moving away from mathematics, what subjects did Whitehead explore?

Answer: philosophy of science, and finally to metaphysics


QUES: Roncalli was elected pope on 28 October 1958 at age 76 after 11 ballots. His selection was unexpected, and Roncalli himself had come to Rome with a return train ticket to Venice. He was the first pope to take the pontifical name of "John" upon election in more than 500 years, and his choice settled the complicated question of official numbering attached to this papal name due to the antipope of this name. Pope John XXIII surprised those who expected him to be a caretaker pope by calling the historic Second Vatican Council (1962–65), the first session opening on 11 October 1962. His passionate views on equality were summed up in his famous statement, "We were all made in God's image, and thus, we are all Godly alike." John XXIII made many passionate speeches during his pontificate, one of which was on the day that he opened the Second Vatican Council in the middle of the night to the crowd gathered in St. Peter's Square: "Dear children, returning home, you will find children: give your children a hug and say: This is a hug from the Pope!"

How long has there been a Pope in Rome?
What is the answer?
ANS:
unanswerable