Problem: In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.
What type of application is filed after completing three phases of human trials?
The answer is the following: New Drug Application

Problem: Significant Russian-speaking groups also exist in Western Europe. These have been fed by several waves of immigrants since the beginning of the 20th century, each with its own flavor of language. The United Kingdom, Spain, Portugal, France, Italy, Belgium, Greece, Brazil, Norway, and Austria have significant Russian-speaking communities. According to the 2011 Census of Ireland, there were 21,639 people in the nation who use Russian as a home language. However, of this only 13% were Russian nationals. 20% held Irish citizenship, while 27% and 14% were holding the passports of Latvia and Lithuania respectively.
How much of Ireland's Russian speakers are Latvian citizens?
The answer is the following: 27%

Problem: On April 4, 2008, Beyoncé married Jay Z. She publicly revealed their marriage in a video montage at the listening party for her third studio album, I Am... Sasha Fierce, in Manhattan's Sony Club on October 22, 2008. I Am... Sasha Fierce was released on November 18, 2008 in the United States. The album formally introduces Beyoncé's alter ego Sasha Fierce, conceived during the making of her 2003 single "Crazy in Love", selling 482,000 copies in its first week, debuting atop the Billboard 200, and giving Beyoncé her third consecutive number-one album in the US. The album featured the number-one song "Single Ladies (Put a Ring on It)" and the top-five songs "If I Were a Boy" and "Halo". Achieving the accomplishment of becoming her longest-running Hot 100 single in her career, "Halo"'s success in the US helped Beyoncé attain more top-ten singles on the list than any other woman during the 2000s. It also included the successful "Sweet Dreams", and singles "Diva", "Ego", "Broken-Hearted Girl" and "Video Phone". The music video for "Single Ladies" has been parodied and imitated around the world, spawning the "first major dance craze" of the Internet age according to the Toronto Star. The video has won several awards, including Best Video at the 2009 MTV Europe Music Awards, the 2009 Scottish MOBO Awards, and the 2009 BET Awards. At the 2009 MTV Video Music Awards, the video was nominated for nine awards, ultimately winning three including Video of the Year. Its failure to win the Best Female Video category, which went to American country pop singer Taylor Swift's "You Belong with Me", led to Kanye West interrupting the ceremony and Beyoncé improvising a re-presentation of Swift's award during her own acceptance speech. In March 2009, Beyoncé embarked on the I Am... World Tour, her second headlining worldwide concert tour, consisting of 108 shows, grossing $119.5 million.
The video for what song won Beyoncé the 2009 MTV Video of the Year award?
The answer is the following: Single Ladies

Problem: The Augustan settlement built upon a cultural shift in Roman society. In the middle Republican era, even Scipio's tentative hints that he might be Jupiter's special protege sat ill with his colleagues. Politicians of the later Republic were less equivocal; both Sulla and Pompey claimed special relationships with Venus. Julius Caesar went further, and claimed her as his ancestress. Such claims suggested personal character and policy as divinely inspired; an appointment to priesthood offered divine validation. In 63 BC, Julius Caesar's appointment as pontifex maximus "signaled his emergence as a major player in Roman politics". Likewise, political candidates could sponsor temples, priesthoods and the immensely popular, spectacular public ludi and munera whose provision became increasingly indispensable to the factional politics of the Late Republic. Under the principate, such opportunities were limited by law; priestly and political power were consolidated in the person of the princeps ("first citizen").
In what year was Cesar made pontifex maximus?
The answer is the following:
63 BC