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During adolescence, the human body undergoes various physical, physiological and immunological changes triggered and mediated by hormones, of which the most significant in females is 17-β-oestradiol (an oestrogen) and, in males, is testosterone. Oestradiol usually begins to act around the age of 10 and testosterone some months later. There is evidence that these steroids act directly not only on the primary and secondary sexual characteristics but also have an effect on the development and regulation of the immune system, including an increased risk in developing pubescent and post-pubescent autoimmunity. There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system.

Which specific hormone precipitates the change in immunology in males?
Answer: testosterone
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He was known affectionately as "Good Pope John". His cause for canonization was opened under Pope Paul VI during the final session of the Second Vatican Council on 18 November 1965, along with the cause of Pope Pius XII. On 3 September 2000, John XXIII was declared "Blessed" alongside Pope Pius IX by Pope John Paul II, the penultimate step on the road to sainthood after a miracle of curing an ill woman was discovered. He was the first pope since Pope Pius X to receive this honour. Following his beatification, his body was moved from its original burial place in the grottoes below the Vatican to the altar of St. Jerome and displayed for the veneration of the faithful.[citation needed]

Who opened his cause for canonization?
Answer: Pope Paul VI
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Federal law originates with the Constitution, which gives Congress the power to enact statutes for certain limited purposes like regulating interstate commerce. The United States Code is the official compilation and codification of the general and permanent federal statutes. Many statutes give executive branch agencies the power to create regulations, which are published in the Federal Register and codified into the Code of Federal Regulations. Regulations generally also carry the force of law under the Chevron doctrine. Many lawsuits turn on the meaning of a federal statute or regulation, and judicial interpretations of such meaning carry legal force under the principle of stare decisis.

Who has the power and right to enact statutes for interstate dealings?
Answer:
Congress