The problem: Answer a question about this article:
The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active.
What are the four factors that determine how the body reacts to an antigen?
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The answer: person's age, antigen type, maternal factors and the area


The problem: Answer a question about this article:
Miami has six major causeways that span over Biscayne Bay connecting the western mainland, with the eastern barrier islands along the Atlantic Ocean. The Rickenbacker Causeway is the southernmost causeway and connects Brickell to Virginia Key and Key Biscayne. The Venetian Causeway and MacArthur Causeway connect Downtown with South Beach. The Julia Tuttle Causeway connects Midtown and Miami Beach. The 79th Street Causeway connects the Upper East Side with North Beach. The northernmost causeway, the Broad Causeway, is the smallest of Miami's six causeways, and connects North Miami with Bal Harbour.
How many major causeways are in Miami?
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The answer: six


The problem: Answer a question about this article:
Von Neumann's ability to instantaneously perform complex operations in his head stunned other mathematicians. Eugene Wigner wrote that, seeing von Neumann's mind at work, "one had the impression of a perfect instrument whose gears were machined to mesh accurately to a thousandth of an inch." Paul Halmos states that "von Neumann's speed was awe-inspiring." Israel Halperin said: "Keeping up with him was ... impossible. The feeling was you were on a tricycle chasing a racing car." Edward Teller wrote that von Neumann effortlessly outdid anybody he ever met, and said "I never could keep up with him". Teller also said "von Neumann would carry on a conversation with my 3-year-old son, and the two of them would talk as equals, and I sometimes wondered if he used the same principle when he talked to the rest of us. Most people avoid thinking if they can, some of us are addicted to thinking, but von Neumann actually enjoyed thinking, maybe even to the exclusion of everything else."
Did von Neumann enjoy thinking?
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The answer: Neumann actually enjoyed thinking, maybe even to the exclusion of everything else.


The problem: Answer a question about this article:
There are several rocks and islets off the coast, including: Castle Rock, Speery Island, the Needle, Lower Black Rock, Upper Black Rock (South), Bird Island (Southwest), Black Rock, Thompson's Valley Island, Peaked Island, Egg Island, Lady's Chair, Lighter Rock (West), Long Ledge (Northwest), Shore Island, George Island, Rough Rock Island, Flat Rock (East), the Buoys, Sandy Bay Island, the Chimney, White Bird Island and Frightus Rock (Southeast), all of which are within one kilometre (0.62 miles) of the shore.
Which direction from the island is Upper Black Rock located?
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The answer:
South