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A permanent European presence in New Netherland began in 1624 – making New York the 12th oldest continuously occupied European-established settlement in the continental United States  – with the founding of a Dutch fur trading settlement on Governors Island. In 1625, construction was started on a citadel and a Fort Amsterdam on Manhattan Island, later called New Amsterdam (Nieuw Amsterdam). The colony of New Amsterdam was centered at the site which would eventually become Lower Manhattan. The Dutch colonial Director-General Peter Minuit purchased the island of Manhattan from the Canarsie, a small band of the Lenape, in 1626 for a value of 60 guilders (about $1000 in 2006); a disproved legend says that Manhattan was purchased for $24 worth of glass beads.

On what island did the Dutch set up a settlement to trade furs?
Answer: Governors Island
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All the major British cities had flourishing department stores by the mid-or late nineteenth century. Increasingly, women became the major shoppers and middle-class households. Kendals (formerly Kendal Milne & Faulkner) in Manchester lays claim to being one of the first department stores and is still known to many of its customers as Kendal's, despite its 2005 name change to House of Fraser. The Manchester institution dates back to 1836 but had been trading as Watts Bazaar since 1796. At its zenith the store had buildings on both sides of Deansgate linked by a subterranean passage "Kendals Arcade" and an art nouveau tiled food hall. The store was especially known for its emphasis on quality and style over low prices giving it the nickname "the Harrods of the North", although this was due in part to Harrods acquiring the store in 1919. Other large Manchester stores included Paulden's (currently Debenhams) and Lewis's (now a Primark).

Who acquired the Manchester store in 1919? 
Answer: Harrods
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The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms, the location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since the activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

How do you predict the clinical result?
Answer:
several pharmacological parameters are used as markers of drug efficacy