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During the turbulent reign of Wang Mang, Han lost control over the Tarim Basin, which was conquered by the Northern Xiongnu in AD 63 and used as a base to invade Han's Hexi Corridor in Gansu. Dou Gu (d. 88 AD) defeated the Northern Xiongnu at the Battle of Yiwulu in AD 73, evicting them from Turpan and chasing them as far as Lake Barkol before establishing a garrison at Hami. After the new Protector General of the Western Regions Chen Mu (d. AD 75) was killed by allies of the Xiongnu in Karasahr and Kucha, the garrison at Hami was withdrawn. At the Battle of Ikh Bayan in AD 89, Dou Xian (d. AD 92) defeated the Northern Xiongnu chanyu who then retreated into the Altai Mountains. After the Northern Xiongnu fled into the Ili River valley in AD 91, the nomadic Xianbei occupied the area from the borders of the Buyeo Kingdom in Manchuria to the Ili River of the Wusun people. The Xianbei reached their apogee under Tanshihuai (檀石槐) (d. AD 180), who consistently defeated Chinese armies. However, Tanshihuai's confederation disintegrated after his death.

Who was the Protector General of the Western Regions?
Chen Mu