There are many missionary groups operating in the country, including Lutherans, Baptists, Catholics, Grace Brethren, and Jehovah's Witnesses. While these missionaries are predominantly from the United States, France, Italy, and Spain, many are also from Nigeria, the Democratic Republic of the Congo, and other African countries. Large numbers of missionaries left the country when fighting broke out between rebel and government forces in 2002–3, but many of them have now returned to continue their work.

What religious groups operate in CAR?