Among the largest non-state-run research institutions in Portugal are the Instituto Gulbenkian de Ciência and the Champalimaud Foundation, a neuroscience and oncology research centre, which in addition awards every year one of the highest monetary prizes of any science prize in the world. A number of both national and multinational high-tech and industrial companies, are also responsible for research and development projects. One of the oldest learned societies of Portugal is the Sciences Academy of Lisbon, founded in 1779.

What are two of the large non-state run research institutions in Portugal?