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According to Genius, the James Gleick-authored biography, Feynman tried LSD during his professorship at Caltech. Somewhat embarrassed by his actions, he largely sidestepped the issue when dictating his anecdotes; he mentions it in passing in the "O Americano, Outra Vez" section, while the "Altered States" chapter in Surely You're Joking, Mr. Feynman! describes only marijuana and ketamine experiences at John Lilly's famed sensory deprivation tanks, as a way of studying consciousness. Feynman gave up alcohol when he began to show vague, early signs of alcoholism, as he did not want to do anything that could damage his brain—the same reason given in "O Americano, Outra Vez" for his reluctance to experiment with LSD.

Why did Feynman give up alcohol?
he did not want to do anything that could damage his brain