After the Voyager 2 flyby mission, the next step in scientific exploration of the Neptunian system, is considered to be a Flagship orbital mission. Such a hypothetical mission is envisioned to be possible at in the late 2020s or early 2030s. However, there have been a couple of discussions to launch Neptune missions sooner. In 2003, there was a proposal in NASA's "Vision Missions Studies" for a "Neptune Orbiter with Probes" mission that does Cassini-level science. Another, more recent proposal was for Argo, a flyby spacecraft to be launched in 2019, that would visit Jupiter, Saturn, Neptune, and a Kuiper belt object. The focus would be on Neptune and its largest moon Triton to be investigated around 2029. The proposed New Horizons 2 mission (which was later scrapped) might also have done a close flyby of the Neptunian system.

When is the next hypothetical mission to Neptune?