St. John's is the eastern terminus of the Trans-Canada Highway, one of the longest national highways in the world. The divided highway, also known as "Outer Ring Road" in the city, runs just outside the main part of the city, with exits to Pitts Memorial Drive, Topsail Road, Team Gushue Highway, Thorburn Road, Allandale Road, Portugal Cove Road and Torbay Road, providing relatively easy access to neighbourhoods served by those streets. Pitts Memorial Drive runs from Conception Bay South, through the city of Mount Pearl and into downtown St. John's, with interchanges for Goulds, Water Street and Hamilton Avenue-New Gower Street.

Where is the eastern terminus of the Trans-Canada Highway?