Hydrogen
Hydrogen gas was first artificially produced in the early 16th century, via the mixing of metals with acids. In 1766–81, Henry Cavendish was the first to recognize that hydrogen gas was a discrete substance, and that it produces water when burned, a property which later gave it its name: in Greek, hydrogen means "water-former".

Q: When was hydrogen gas artificially produced for the first time?
early 16th century