Problem: The isolation of enzymes from infected tissue can also provide the basis of a biochemical diagnosis of an infectious disease. For example, humans can make neither RNA replicases nor reverse transcriptase, and the presence of these enzymes are characteristic of specific types of viral infections. The ability of the viral protein hemagglutinin to bind red blood cells together into a detectable matrix may also be characterized as a biochemical test for viral infection, although strictly speaking hemagglutinin is not an enzyme and has no metabolic function.
What does the protein hemagglutinin bind together?
The answer is the following: red blood cells


In 1968 Ronald Melzack and Kenneth Casey described pain in terms of its three dimensions: "sensory-discriminative" (sense of the intensity, location, quality and duration of the pain), "affective-motivational" (unpleasantness and urge to escape the unpleasantness), and "cognitive-evaluative" (cognitions such as appraisal, cultural values, distraction and hypnotic suggestion). They theorized that pain intensity (the sensory discriminative dimension) and unpleasantness (the affective-motivational dimension) are not simply determined by the magnitude of the painful stimulus, but "higher" cognitive activities can influence perceived intensity and unpleasantness. Cognitive activities "may affect both sensory and affective experience or they may modify primarily the affective-motivational dimension. Thus, excitement in games or war appears to block both dimensions of pain, while suggestion and placebos may modulate the affective-motivational dimension and leave the sensory-discriminative dimension relatively undisturbed." (p. 432) The paper ends with a call to action: "Pain can be treated not only by trying to cut down the sensory input by anesthetic block, surgical intervention and the like, but also by influencing the motivational-affective and cognitive factors as well." (p. 435)
How many dimensions did Melzack and Casey describe pain in terms of?
three


Input: North Carolina
As early as 1650, settlers from the Virginia colony moved into the area of Albemarle Sound. By 1663, King Charles II of England granted a charter to start a new colony on the North American continent; it generally established North Carolina's borders. He named it Carolina in honor of his father Charles I. By 1665, a second charter was issued to attempt to resolve territorial questions. In 1710, owing to disputes over governance, the Carolina colony began to split into North Carolina and South Carolina. The latter became a crown colony in 1729.

What year did King Charles II grant a charter to North America?
Output: 1663


Input: Article: Advances were made in irrigation and farming, using new technology such as the windmill. Crops such as almonds and citrus fruit were brought to Europe through al-Andalus, and sugar cultivation was gradually adopted by the Europeans. Arab merchants dominated trade in the Indian Ocean until the arrival of the Portuguese in the 16th century. Hormuz was an important center for this trade. There was also a dense network of trade routes in the Mediterranean, along which Muslim countries traded with each other and with European powers such as Venice, Genoa and Catalonia. The Silk Road crossing Central Asia passed through Muslim states between China and Europe.

Now answer this question: Where was an important center of Indian Ocean trading in the 16th century?

Output: Hormuz


Article: The concept of nobility flourished in New Spain in a way not seen in other parts of the Americas. Spaniards encountered a society in which the concept of nobility mirrored that of their own. Spaniards respected the indigenous order of nobility and added to it. In the ensuing centuries, possession of a noble title in Mexico did not mean one exercised great political power, for one's power was limited even if the accumulation of wealth was not. The concept of nobility in Mexico was not political but rather a very conservative Spanish social one, based on proving the worthiness of the family. Most of these families proved their worth by making fortunes in New Spain outside of the city itself, then spending the revenues in the capital, building churches, supporting charities and building extravagant palatial homes. The craze to build the most opulent residence possible reached its height in the last half of the 18th century. Many of these palaces can still be seen today, leading to Mexico City's nickname of "The city of palaces" given by Alexander Von Humboldt.

Question: What is a common nickname for Mexico City?
Ans: The city of palaces


Input: Zinc
Several dozen radioisotopes have been characterized. 65Zn, which has a half-life of 243.66 days, is the most long-lived radioisotope, followed by 72Zn with a half-life of 46.5 hours. Zinc has 10 nuclear isomers. 69mZn has the longest half-life, 13.76 h. The superscript m indicates a metastable isotope. The nucleus of a metastable isotope is in an excited state and will return to the ground state by emitting a photon in the form of a gamma ray. 61Zn has three excited states and 73Zn has two. The isotopes 65Zn, 71Zn, 77Zn and 78Zn each have only one excited state.

What is the most long lived radio isotope?
Output:
65Zn