Problem: Pharmaceutical industry:

By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.

In what year was epinephrine discovered?
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A: 1897


Problem: Economy of Greece:

The evolution of the Greek economy during the 19th century (a period that transformed a large part of the world because of the Industrial Revolution) has been little researched. Recent research from 2006 examines the gradual development of industry and further development of shipping in a predominantly agricultural economy, calculating an average rate of per capita GDP growth between 1833 and 1911 that was only slightly lower than that of the other Western European nations. Industrial activity, (including heavy industry like shipbuilding) was evident, mainly in Ermoupolis and Piraeus. Nonetheless, Greece faced economic hardships and defaulted on its external loans in 1826, 1843, 1860 and 1894.

What did Greece avoid in 1826, 1843, 1860 and 1894?
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A: unanswerable


Problem: The Bronx:

The Bronx has several local newspapers, including The Bronx News, Parkchester News, City News, The Riverdale Press, Riverdale Review, The Bronx Times Reporter, Inner City Press  (which now has more of a focus on national issues) and Co-Op City Times. Four non-profit news outlets, Norwood News, Mount Hope Monitor, Mott Haven Herald and The Hunts Point Express serve the borough's poorer communities. The editor and co-publisher of The Riverdale Press, Bernard Stein, won the Pulitzer Prize for Editorial Writing for his editorials about Bronx and New York City issues in 1998. (Stein graduated from the Bronx High School of Science in 1959.)

When did Stein win a Pulitzer?
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A: 1998


Problem: Compact disc:

CDs are susceptible to damage during handling and from environmental exposure. Pits are much closer to the label side of a disc, enabling defects and contaminants on the clear side to be out of focus during playback. Consequently, CDs are more likely to suffer damage on the label side of the disc. Scratches on the clear side can be repaired by refilling them with similar refractive plastic or by careful polishing. The edges of CDs are sometimes incompletely sealed, allowing gases and liquids to corrode the metal reflective layer and to interfere with the focus of the laser on the pits. The fungus Geotrichum candidum, found in Belize, has been found to consume the polycarbonate plastic and aluminium found in CDs.

How are scratches on the labeled side of a disc fixed?
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A:
unanswerable