Problem: The third generation began including a 30-pin dock connector, allowing for FireWire or USB connectivity. This provided better compatibility with non-Apple machines, as most of them did not have FireWire ports at the time. Eventually Apple began shipping iPods with USB cables instead of FireWire, although the latter was available separately. As of the first-generation iPod Nano and the fifth-generation iPod Classic, Apple discontinued using FireWire for data transfer (while still allowing for use of FireWire to charge the device) in an attempt to reduce cost and form factor. As of the second-generation iPod Touch and the fourth-generation iPod Nano, FireWire charging ability has been removed. The second-, third-, and fourth-generation iPod Shuffle uses a single 3.5 mm minijack phone connector which acts as both a headphone jack and a data port for the dock.
What interface was gradually phased out for both charging and data transfer?
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Answer: FireWire


Problem: As the Tokugawa period progressed more value became placed on education, and the education of females beginning at a young age became important to families and society as a whole. Marriage criteria began to weigh intelligence and education as desirable attributes in a wife, right along with physical attractiveness. Though many of the texts written for women during the Tokugawa period only pertained to how a woman could become a successful wife and household manager, there were those that undertook the challenge of learning to read, and also tackled philosophical and literary classics. Nearly all women of the samurai class were literate by the end of the Tokugawa period.
What were added to marriage criteria in the Tokugawa period?
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Answer: intelligence and education as desirable attributes


Problem: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
How much does it cost to develop approvals?
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Answer:
unanswerable