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In 1903 Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs. The discovery was patented and licensed to Bayer pharmaceuticals, which marketed the compound under the trade name Veronal as a sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of phenobarbital at Bayer in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on the World Health Organizations list of essential medications. The 1950s and 1960s saw increased awareness of the addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers. Today, amphetamine is largely restricted to use in the treatment of attention deficit disorder and phenobarbital in the treatment of epilepsy.

Who discovered a reaction that induced sleep in dogs?
Answer: Hermann Emil Fischer and Joseph von Mering
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Lions are said to inhabit the mountains of the Gash-Barka Region. There is also a small population of elephants that roam in some parts of the country. Dik-diks can also be found in many areas. The endangered African wild ass can be seen in Denakalia Region. Other local wildlife include bushbucks, duikers, greater kudus, klipspringers, African leopards, oryxs and crocodiles., The spotted hyena is widespread and fairly common. Between 1955 and 2001 there were no reported sightings of elephant herds, and they are thought to have fallen victim to the war of independence. In December 2001 a herd of about 30, including 10 juveniles, was observed in the vicinity of the Gash River. The elephants seemed to have formed a symbiotic relationship with olive baboons, with the baboons using the water holes dug by the elephants, while the elephants use the tree-top baboons as an early warning system.

What species did the elephants at the Gash River seem to form a symbiotic relationship with?
Answer: olive baboons
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Louis XVI translated the Reflections "from end to end" into French. Fellow Whig MPs Richard Sheridan and Charles James Fox, disagreed with Burke and split with him. Fox thought the Reflections to be "in very bad taste" and "favouring Tory principles". Other Whigs such as the Duke of Portland and Earl Fitzwilliam privately agreed with Burke, but did not wish for a public breach with their Whig colleagues. Burke wrote on 29 November 1790: "I have received from the Duke of Portland, Lord Fitzwilliam, the Duke of Devonshire, Lord John Cavendish, Montagu (Frederick Montagu MP), and a long et cetera of the old Stamina of the Whiggs a most full approbation of the principles of that work and a kind indulgence to the execution". The Duke of Portland said in 1791 that when anyone criticised the Reflections to him, he informed them that he had recommended the book to his sons as containing the true Whig creed.

Which British ministers disagreed with Burke's Reflections?
Answer:
Richard Sheridan and Charles James Fox