Problem: Circadian rhythm:

What drove circadian rhythms to evolve has been an enigmatic question. Previous hypotheses emphasized that photosensitive proteins and circadian rhythms may have originated together in the earliest cells, with the purpose of protecting replicating DNA from high levels of damaging ultraviolet radiation during the daytime. As a result, replication was relegated to the dark. However, evidence for this is lacking, since the simplest organisms with a circadian rhythm, the cyanobacteria, do the opposite of this - they divide more in the daytime. Recent studies instead highlight the importance of co-evolution of redox proteins with circadian oscillators in all three kingdoms of life following the Great Oxidation Event approximately 2.3 billion years ago. The current view is that circadian changes in environmental oxygen levels and the production of reactive oxygen species (ROS) in the presence of daylight are likely to have driven a need to evolve circadian rhythms to preempt, and therefore counteract, damaging redox reactions on a daily basis.

What simple organism provides evidence the DNA replicates at night?
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A: unanswerable


Problem: By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extracts were of particular interest to surgeons as hemostatic agents and as treatment for shock, and a number of companies developed products based on adrenal extracts containing varying purities of the active substance. In 1897 John Abel of Johns Hopkins University identified the active principle as epinephrine, which he isolated in an impure state as the sulfate salt. Industrial chemist Jokichi Takamine later developed a method for obtaining epinephrine in a pure state, and licensed the technology to Parke Davis. Parke Davis marketed epinephrine under the trade name Adrenalin. Injected epinephrine proved to be especially efficacious for the acute treatment of asthma attacks, and an inhaled version was sold in the United States until 2011 (Primatene Mist). By 1929 epinephrine had been formulated into an inhaler for use in the treatment of nasal congestion.
What is epinephrine used to treat?
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Answer: asthma attacks


Q: What is a question about this article? If the question is unanswerable, say "unanswerable".
London i/ˈlʌndən/ is the capital and most populous city of England and the United Kingdom. Standing on the River Thames in the south eastern part of the island of Great Britain, London has been a major settlement for two millennia. It was founded by the Romans, who named it Londinium. London's ancient core, the City of London, largely retains its 1.12-square-mile (2.9 km2) medieval boundaries and in 2011 had a resident population of 7,375, making it the smallest city in England. Since at least the 19th century, the term London has also referred to the metropolis developed around this core. The bulk of this conurbation forms Greater London,[note 1] a region of England governed by the Mayor of London and the London Assembly.[note 2] The conurbation also covers two English counties: the small district of the City of London and the county of Greater London. The latter constitutes the vast majority of London, though historically it was split between Middlesex (a now abolished county), Essex, Surrey, Kent and Hertfordshire.
As of 2011 what was the population of the core of London?
A: 7,375


Context and question: General Aguirre moved to the deserts of the southeastern portion of the state and defeated the French forces in Parral, led by Colonel Cottret. By the middle of 1866, the state of Chihuahua was declared free of enemy control; Parral was the last French stronghold within the state. On June 17, 1866, President Juárez arrived in Chihuahua City and remained in the capital until December 10, 1866. During his two years in the state of Chihuahua, President Juárez passed ordinances regarding the rights of adjudication of property and nationalized the property of the clergy. The distance of the French forces and their allies allowed the Ministry of War, led by General Negrete, to reorganize the state's national guard into the Patriotic Battalion of Chihuahua, which was deployed to fight in the battle of Matamoros, Tamaulipas against the French. After a series of major defeats and an escalating threat from Prussia, France began pulling troops out of Mexico in late 1866. Disillusioned with the liberal political views of Maximilian, the Mexican conservatives abandoned him, and in 1867 the last of the Emperor's forces were defeated. Maximilian was sentenced to death by a military court; despite national and international pleas for amnesty, Juárez refused to commute the sentence. Maximilian was executed by firing squad on June 19, 1867.
During which year was Chihuahua declared free of enemy control?
Answer: 1866


Question: The British adopted "effective ceiling", meaning the altitude at which a gun could deliver a series of shells against a moving target; this could be constrained by maximum fuse running time as well as the gun's capability. By the late 1930s the British definition was "that height at which a directly approaching target at 400 mph (=643.6 km/h) can be engaged for 20 seconds before the gun reaches 70 degrees elevation". However, effective ceiling for heavy AA guns was affected by non-ballistic factors:
Is there an answer to this question: Along with other factors, how long must a target be engaged to have effective ceiling?

Answer: for 20 seconds


QUES: For nearly 2000 years, Sanskrit was the language of a cultural order that exerted influence across South Asia, Inner Asia, Southeast Asia, and to a certain extent East Asia. A significant form of post-Vedic Sanskrit is found in the Sanskrit of Indian epic poetry—the Ramayana and Mahabharata. The deviations from Pāṇini in the epics are generally considered to be on account of interference from Prakrits, or innovations, and not because they are pre-Paninian. Traditional Sanskrit scholars call such deviations ārṣa (आर्ष), meaning 'of the ṛṣis', the traditional title for the ancient authors. In some contexts, there are also more "prakritisms" (borrowings from common speech) than in Classical Sanskrit proper. Buddhist Hybrid Sanskrit is a literary language heavily influenced by the Middle Indo-Aryan languages, based on early Buddhist Prakrit texts which subsequently assimilated to the Classical Sanskrit standard in varying degrees.

What did Classic Sanskrit assimilate to?
What is the answer?
ANS:
unanswerable