Southampton is home to Southampton Football Club—nicknamed "The Saints"—who play in the Premier League at St Mary's Stadium, having relocated in 2001 from their 103-year-old former stadium, "The Dell". They reached the top flight of English football (First Division) for the first time in 1966, staying there for eight years. They lifted the FA Cup with a shock victory over Manchester United in 1976, returned to the top flight two years later, and stayed there for 27 years (becoming founder members of the Premier League in 1992) before they were relegated in 2005. The club was promoted back to the Premier League in 2012 following a brief spell in the third-tier and severe financial difficulties. In 2015, "The Saints" finished 7th in the Premier League, their highest league finish in 30 years, after a remarkable season under new manager Ronald Koeman. Their highest league position came in 1984 when they were runners-up in the old First Division. They were also runners-up in the 1979 Football League Cup final and 2003 FA Cup final. Notable former managers include Ted Bates, Lawrie McMenemy, Chris Nicholl, Ian Branfoot and Gordon Strachan. There is a strong rivalry between Portsmouth F.C. ("South Coast derby") which is located only about 30 km (19 mi) away.

What's the nickname of the Southampton Football Club?