The foundation has donated billions of dollars to help sufferers of AIDS, tuberculosis and malaria, protecting millions of children from death at the hands of preventable diseases. However, a 2007 investigation by The Los Angeles Times claimed there are three major unintended consequences with the foundation's allocation of aid. First, sub-Saharan Africa already suffered from a shortage of primary doctors before the arrival of the Gates Foundation, but "by pouring most contributions into the fight against such high-profile killers as AIDS, Gates grantees have increased the demand for specially trained, higher-paid clinicians, diverting staff from basic care" in sub-Saharan Africa. This "brain drain" adds to the existing doctor shortage and pulls away additional trained staff from children and those suffering from other common killers. Second, "the focus on a few diseases has shortchanged basic needs such as nutrition and transportation". Third, "Gates-funded vaccination programs have instructed caregivers to ignore – even discourage patients from discussing – ailments that the vaccinations cannot prevent".

The foundation has donated billions to sufferers of