Plymouth has the first known reference to Jews in the South West from Sir Francis Drake's voyages in 1577 to 1580, as his log mentioned "Moses the Jew" – a man from Plymouth. The Plymouth Synagogue is a Listed Grade II* building, built in 1762 and is the oldest Ashkenazi Synagogue in the English speaking world. There are also places of worship for Islam, Bahá'í, Buddhism, Unitarianism, Chinese beliefs and Humanism.

What Plymouth Jew was mentioned by Sir Francis Drake?