Article: The "Radical Enlightenment" promoted the concept of separating church and state, an idea that often credited to English philosopher John Locke (1632–1704). According to his principle of the social contract, Locke said that the government lacked authority in the realm of individual conscience, as this was something rational people could not cede to the government for it or others to control. For Locke, this created a natural right in the liberty of conscience, which he said must therefore remain protected from any government authority.

Question: In what realm did John Locke feel the government lacked authority?
Ans: the realm of individual conscience


Article: The central oscillator generates a self-sustaining rhythm and is driven by two interacting feedback loops that are active at different times of day. The morning loop consists of CCA1 (Circadian and Clock-Associated 1) and LHY (Late Elongated Hypocotyl), which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 (Pseudo-Response Regulators.) The evening loop consists of GI (Gigantea) and ELF4, both involved in regulation of flowering time genes. When CCA1 and LHY are overexpressed (under constant light or dark conditions), plants become arrhythmic, and mRNA signals reduce, contributing to a negative feedback loop. Gene expression of CCA1 and LHY oscillates and peaks in the early morning, whereas TOC1 gene expression oscillates and peaks in the early evening. While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY repress TOC1 and over-expressed TOC1 is a positive regulator of CCA1 and LHY, it was shown in 2012 by Andrew Millar and others that TOC1 in fact serves as a repressor not only of CCA1, LHY, and PRR7 and 9 in the morning loop but also of GI and ELF4 in the evening loop. This finding and further computational modeling of TOC1 gene functions and interactions suggest a reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing the clock in mammals.

Question: What researcher showed that the gene  feedback loop serves as a repressor?
Ans: Andrew Millar


Article: At the 52nd Annual Grammy Awards, Beyoncé received ten nominations, including Album of the Year for I Am... Sasha Fierce, Record of the Year for "Halo", and Song of the Year for "Single Ladies (Put a Ring on It)", among others. She tied with Lauryn Hill for most Grammy nominations in a single year by a female artist. In 2010, Beyoncé was featured on Lady Gaga's single "Telephone" and its music video. The song topped the US Pop Songs chart, becoming the sixth number-one for both Beyoncé and Gaga, tying them with Mariah Carey for most number-ones since the Nielsen Top 40 airplay chart launched in 1992. "Telephone" received a Grammy Award nomination for Best Pop Collaboration with Vocals.

Question: Who else appeared with Beyonce in Telephone?
Ans: Lady Gaga


Article: The Amoy dialect (Xiamen) is a hybrid of the Quanzhou and Zhangzhou dialects. Taiwanese is also a hybrid of these two dialects. Taiwanese in northern Taiwan tends to be based on the Quanzhou variety, whereas the Taiwanese spoken in southern Taiwan tends to be based on Zhangzhou speech. There are minor variations in pronunciation and vocabulary between Quanzhou and Zhangzhou dialects. The grammar is generally the same. Additionally, extensive contact with the Japanese language has left a legacy of Japanese loanwords in Taiwanese Hokkien. On the other hand, the variants spoken in Singapore and Malaysia have a substantial number of loanwords from Malay and to a lesser extent, from English and other Chinese varieties, such as the closely related Teochew and some Cantonese.

Question: The Amoy dialect is a hybrid of what two dialects?
Ans:
Quanzhou and Zhangzhou