Problem: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
What is the approximate cost of developing a new drug, including the costs of failure?
The answer is the following: 1.3 billion USD

Problem: About that time the "executionist movement" (Polish: "egzekucja praw"--"execution of the laws") began to take form. Its members would seek to curb the power of the magnates at the Sejm and to strengthen the power of king and country. In 1562 at the Sejm in Piotrków they would force the magnates to return many leased crown lands to the king, and the king to create a standing army (wojsko kwarciane). One of the most famous members of this movement was Jan Zamoyski. After his death in 1605, the movement lost its political force.
What happened when Jan Zamoyski died?
The answer is the following: movement lost its political force.

Problem: It was not long until Apple released their first portable computer, the Macintosh Portable in 1989. Although due to considerable design issues, it was soon replaced in 1991 with the first of the PowerBook line: the PowerBook 100, a miniaturized portable; the 16 MHz 68030 PowerBook 140; and the 25 MHz 68030 PowerBook 170. They were the first portable computers with the keyboard behind a palm rest and a built-in pointing device (a trackball) in front of the keyboard. The 1993 PowerBook 165c was Apple's first portable computer to feature a color screen, displaying 256 colors with 640 x 400-pixel resolution. The second generation of PowerBooks, the 68040-equipped 500 series, introduced trackpads, integrated stereo speakers, and built-in Ethernet to the laptop form factor in 1994.
Which generation of PowerBooks introduced trackpads?
The answer is the following: second

Problem: Von Neumann continued unperturbed in his work and became, along with Edward Teller, one of those who sustained the hydrogen bomb project. He then collaborated with Klaus Fuchs on further development of the bomb, and in 1946 the two filed a secret patent on "Improvement in Methods and Means for Utilizing Nuclear Energy", which outlined a scheme for using a fission bomb to compress fusion fuel to initiate nuclear fusion. The Fuchs–von Neumann patent used radiation implosion, but not in the same way as is used in what became the final hydrogen bomb design, the Teller–Ulam design. Their work was, however, incorporated into the "George" shot of Operation Greenhouse, which was instructive in testing out concepts that went into the final design. The Fuchs–von Neumann work was passed on, by Fuchs, to the Soviet Union as part of his nuclear espionage, but it was not used in the Soviets' own, independent development of the Teller–Ulam design. The historian Jeremy Bernstein has pointed out that ironically, "John von Neumann and Klaus Fuchs, produced a brilliant invention in 1946 that could have changed the whole course of the development of the hydrogen bomb, but was not fully understood until after the bomb had been successfully made."
What improvement did von Neumann see in the nuclear weaponry?
The answer is the following:
using a fission bomb to compress fusion fuel to initiate nuclear fusion