Primary resistance occurs when a person becomes infected with a resistant strain of TB. A person with fully susceptible MTB may develop secondary (acquired) resistance during therapy because of inadequate treatment, not taking the prescribed regimen appropriately (lack of compliance), or using low-quality medication. Drug-resistant TB is a serious public health issue in many developing countries, as its treatment is longer and requires more expensive drugs. MDR-TB is defined as resistance to the two most effective first-line TB drugs: rifampicin and isoniazid. Extensively drug-resistant TB is also resistant to three or more of the six classes of second-line drugs. Totally drug-resistant TB is resistant to all currently used drugs. It was first observed in 2003 in Italy, but not widely reported until 2012, and has also been found in Iran and India. Bedaquiline is tentatively supported for use in multiple drug-resistant TB.
Cases of totally drug-resistant TB have been found in what country in addition to Italy and India?
Iran

Since 2006, $9 billion has been invested in downtown and surrounding neighborhoods; $5.2 billion of that in has come in 2013 and 2014. Construction activity, particularly rehabilitation of historic downtown buildings, has increased markedly. The number of vacant downtown buildings has dropped from nearly 50 to around 13.[when?] Among the most notable redevelopment projects are the Book Cadillac Hotel and the Fort Shelby Hotel; the David Broderick Tower; and the David Whitney Building. Meanwhile, work is underway or set to begin on the historic, vacant Wurlitzer Building and Strathmore Hotel.[citation needed]
How much has been invested in Detroit since 2006?
$9 billion

Jehovah's Witnesses are best known for their door-to-door preaching, distributing literature such as The Watchtower and Awake!, and refusing military service and blood transfusions. They consider use of the name Jehovah vital for proper worship. They reject Trinitarianism, inherent immortality of the soul, and hellfire, which they consider to be unscriptural doctrines. They do not observe Christmas, Easter, birthdays or other holidays and customs they consider to have pagan origins incompatible with Christianity. Adherents commonly refer to their body of beliefs as "the truth" and consider themselves to be "in the truth". They consider secular society to be morally corrupt and under the influence of Satan, and most limit their social interaction with non-Witnesses. Congregational disciplinary actions include disfellowshipping, their term for formal expulsion and shunning. Baptized individuals who formally leave are considered disassociated and are also shunned. Disfellowshipped and disassociated individuals may eventually be reinstated if deemed repentant.
What are Jehovah witnesses best known for?
their door-to-door preaching