Problem: Please answer a question about the following article about Materialism:
In Ancient Indian philosophy, materialism developed around 600 BC with the works of Ajita Kesakambali, Payasi, Kanada, and the proponents of the Cārvāka school of philosophy. Kanada became one of the early proponents of atomism. The Nyaya–Vaisesika school (600 BC - 100 BC) developed one of the earliest forms of atomism, though their proofs of God and their positing that the consciousness was not material precludes labelling them as materialists. Buddhist atomism and the Jaina school continued the atomic tradition.
At that time, who helped develop materialism?
A: Ajita Kesakambali, Payasi, Kanada, and the proponents of the Cārvāka school of philosophy


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The central oscillator generates a self-sustaining rhythm and is driven by two interacting feedback loops that are active at different times of day. The morning loop consists of CCA1 (Circadian and Clock-Associated 1) and LHY (Late Elongated Hypocotyl), which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 (Pseudo-Response Regulators.) The evening loop consists of GI (Gigantea) and ELF4, both involved in regulation of flowering time genes. When CCA1 and LHY are overexpressed (under constant light or dark conditions), plants become arrhythmic, and mRNA signals reduce, contributing to a negative feedback loop. Gene expression of CCA1 and LHY oscillates and peaks in the early morning, whereas TOC1 gene expression oscillates and peaks in the early evening. While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY repress TOC1 and over-expressed TOC1 is a positive regulator of CCA1 and LHY, it was shown in 2012 by Andrew Millar and others that TOC1 in fact serves as a repressor not only of CCA1, LHY, and PRR7 and 9 in the morning loop but also of GI and ELF4 in the evening loop. This finding and further computational modeling of TOC1 gene functions and interactions suggest a reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing the clock in mammals.

What researcher showed that the gene  feedback loop serves as a repressor?
Answer: Andrew Millar


Problem: Starting one-hundred years before the 20th century, the enlightenment spiritual philosophy was challenged in various quarters around the 1900s. Developed from earlier secular traditions, modern Humanist ethical philosophies affirmed the dignity and worth of all people, based on the ability to determine right and wrong by appealing to universal human qualities, particularly rationality, without resorting to the supernatural or alleged divine authority from religious texts. For liberal humanists such as Rousseau and Kant, the universal law of reason guided the way toward total emancipation from any kind of tyranny. These ideas were challenged, for example by the young Karl Marx, who criticized the project of political emancipation (embodied in the form of human rights), asserting it to be symptomatic of the very dehumanization it was supposed to oppose. For Friedrich Nietzsche, humanism was nothing more than a secular version of theism. In his Genealogy of Morals, he argues that human rights exist as a means for the weak to collectively constrain the strong. On this view, such rights do not facilitate emancipation of life, but rather deny it. In the 20th century, the notion that human beings are rationally autonomous was challenged by the concept that humans were driven by unconscious irrational desires.
Why does Friedrinch Netzsche believe human rights exist?
The answer is the following: as a means for the weak to collectively constrain the strong.


Some states distinguish between two levels: felonies and misdemeanors (minor crimes). Generally, most felony convictions result in lengthy prison sentences as well as subsequent probation, large fines, and orders to pay restitution directly to victims; while misdemeanors may lead to a year or less in jail and a substantial fine. To simplify the prosecution of traffic violations and other relatively minor crimes, some states have added a third level, infractions. These may result in fines and sometimes the loss of one's driver's license, but no jail time.
What is a third level of crime that some states have adopted?
infractions


Input: Mandolin
The transition from the mandolino to the mandolin began around 1744 with the designing of the metal-string mandolin by the Vinaccia family, 3 brass strings and one of gut, using friction tuning pegs on a fingerboard that sat "flush" with the sound table. The mandolin grew in popularity over the next 60 years, in the streets where it was used by young men courting and by street musicians, and in the concert hall. After the Napoleonic Wars of 1815, however, its popularity began to fall. The 19th century produced some prominent players, including Bartolomeo Bortolazzi of Venice and Pietro Vimercati. However, professional virtuosity was in decline, and the mandolin music changed as the mandolin became a folk instrument; "the large repertoire of notated instrumental music for the mandolino and the mandoline was completely forgotten". The export market for mandolins from Italy dried up around 1815, and when Carmine de Laurentiis wrote a mandolin method in 1874, the Music World magazine wrote that the mandolin was "out of date." Salvador Léonardi mentioned this decline in his 1921 book, Méthode pour Banjoline ou Mandoline-Banjo, saying that the mandolin had been declining in popularity from previous times.

What year did the export market for manodlins from Italy dry up?
Output: 1815


Problem: Please answer a question about the following article about Dissolution of the Soviet Union:
In May 1985, Gorbachev delivered a speech in Leningrad advocating reforms and an anti-alcohol campaign to tackle widespread alcoholism. Prices on vodka, wine, and beer were raised in order to make these drinks more expensive and a disincentive to consumers, and the introduction of rationing. Unlike most forms of rationing intended to conserve scarce goods, this was done to restrict sales with the overt goal of curtailing drunkenness. Gorbachev's plan also included billboards promoting sobriety, increased penalties for public drunkenness, and to censor drinking scenes from old movies. Although this program was not a direct copycat of Tsar Nicholas II's outright prohibition during World War I, Gorbachev faced the same adverse economic reaction as did the last Tsar. The disincentivization of alcohol consumption was a serious blow to the state budget according to Alexander Yakovlev, who noted annual collections of alcohol taxes decreased by 100 billion rubles. Alcohol production migrated to the black market, or through moonshining as some made "bathtub vodka" with homegrown potatoes. Poorer, less educated Russians resorted to drinking unhealthy substitutes such as nail polish, rubbing alcohol or men's cologne, which only served to be an additional burden on Russia's healthcare sector due to the subsequent poisoning cases. The purpose of these reforms, however, was to prop up the existing centrally planned economy, unlike later reforms, which tended toward market socialism.
When was Gorbachev's speech addressing alcohol abuse?
A:
May 1985