Caesar was now the primary figure of the Roman state, enforcing and entrenching his powers. His enemies feared that he had ambitions to become an autocratic ruler. Arguing that the Roman Republic was in danger, a group of senators hatched a conspiracy and assassinated Caesar at a meeting of the Senate in March 44 BC.  Mark Antony, Caesar's lieutenant, condemned Caesar's assassination, and war broke out between the two factions. Antony was denounced as a public enemy, and Caesar's adopted son and chosen heir, Gaius Octavianus, was entrusted with the command of the war against him. At the Battle of Mutina Mark Antony was defeated by the consuls Hirtius and Pansa, who were both killed.

Who was now considered to be the primary figure in the Roman state?