Here is a question about this article: The central oscillator generates a self-sustaining rhythm and is driven by two interacting feedback loops that are active at different times of day. The morning loop consists of CCA1 (Circadian and Clock-Associated 1) and LHY (Late Elongated Hypocotyl), which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 (Pseudo-Response Regulators.) The evening loop consists of GI (Gigantea) and ELF4, both involved in regulation of flowering time genes. When CCA1 and LHY are overexpressed (under constant light or dark conditions), plants become arrhythmic, and mRNA signals reduce, contributing to a negative feedback loop. Gene expression of CCA1 and LHY oscillates and peaks in the early morning, whereas TOC1 gene expression oscillates and peaks in the early evening. While it was previously hypothesised that these three genes model a negative feedback loop in which over-expressed CCA1 and LHY repress TOC1 and over-expressed TOC1 is a positive regulator of CCA1 and LHY, it was shown in 2012 by Andrew Millar and others that TOC1 in fact serves as a repressor not only of CCA1, LHY, and PRR7 and 9 in the morning loop but also of GI and ELF4 in the evening loop. This finding and further computational modeling of TOC1 gene functions and interactions suggest a reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing the clock in mammals.
What is the answer to this question: What produces a self-sustaining rhythm?
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So... central oscillator


The problem: Answer a question about this article:
When the Frankish rulers established the system of feudalism, the Bishops of Utrecht came to exercise worldly power as prince-bishops. The territory of the bishopric not only included the modern province of Utrecht (Nedersticht, 'lower Sticht'), but also extended to the northeast. The feudal conflict of the Middle Ages heavily affected Utrecht. The prince-bishopric was involved in almost continuous conflicts with the Counts of Holland and the Dukes of Guelders. The Veluwe region was seized by Guelders, but large areas in the modern province of Overijssel remained as the Oversticht.
What hapend when Frankish rulers established the system of feudalism
****
The answer: the Bishops of Utrecht came to exercise worldly power as prince-bishops


Problem: Please answer a question about the following article about Copper:
Copper is an essential trace element in plants and animals, but not some microorganisms. The human body contains copper at a level of about 1.4 to 2.1 mg per kg of body mass. Stated differently, the RDA for copper in normal healthy adults is quoted as 0.97 mg/day and as 3.0 mg/day. Copper is absorbed in the gut, then transported to the liver bound to albumin. After processing in the liver, copper is distributed to other tissues in a second phase. Copper transport here involves the protein ceruloplasmin, which carries the majority of copper in blood. Ceruloplasmin also carries copper that is excreted in milk, and is particularly well-absorbed as a copper source. Copper in the body normally undergoes enterohepatic circulation (about 5 mg a day, vs. about 1 mg per day absorbed in the diet and excreted from the body), and the body is able to excrete some excess copper, if needed, via bile, which carries some copper out of the liver that is not then reabsorbed by the intestine.
What protein carries the majority of copper in blood?
A: Ceruloplasmin


Question: Read this and answer the question

Media outlets began reporting in late September 2009 that Comcast was in talks to buy NBCUniversal. Comcast denied the rumors at first, while NBC would not comment on them. However, CNBC itself reported on October 1 that General Electric was considering spinning NBCUniversal off into a separate company that would merge the NBC television network and its cable properties such as USA Network, Syfy and MSNBC with Comcast's content assets. GE would maintain 49% control of the new company, while Comcast owned 51%. Vivendi, which owns 20%, would have to sell its stake to GE. It was reported that under the current deal with GE that it would happen in November or December. It was also reported that Time Warner would be interested in placing a bid, until CEO Jeffrey L. Bewkes directly denied interest, leaving Comcast the sole bidder. On November 1, 2009, The New York Times reported Comcast had moved closer to a deal to purchase NBCUniversal and that a formal announcement could be made sometime the following week.

What media conglomerate did Comcast begin preliminary talks to buy in 2009?
Answer: NBCUniversal


Problem: Pubs may be venues for pub songs and live music. During the 1970s pubs provided an outlet for a number of bands, such as Kilburn and the High Roads, Dr. Feelgood and The Kursaal Flyers, who formed a musical genre called Pub rock that was a precursor to Punk music.
In what decade was Pub rock popular?
The answer is the following: the 1970s


Input: Article: The early Manchu rulers also established two foundations of legitimacy which help to explain the stability of their dynasty. The first was the bureaucratic institutions and the neo-Confucian culture which they adopted from earlier dynasties. Manchu rulers and Han Chinese scholar-official elites gradually came to terms with each other. The examination system offered a path for ethnic Han to become officials. Imperial patronage of Kangxi Dictionary demonstrated respect for Confucian learning, while the Sacred Edict of 1670 effectively extolled Confucian family values. The second major source of stability was the Central Asian aspect of their Manchu identity which allowed them to appeal to Mongol, Tibetan and Uighur constituents. The Qing used the title of Emperor (Huangdi) in Chinese while among Mongols the Qing monarch was referred to as Bogda khan (wise Khan), and referred to as Gong Ma in Tibet. Qianlong propagated the image of himself as Buddhist sage rulers, patrons of Tibetan Buddhism. In the Manchu language, the Qing monarch was alternately referred to as either Huwangdi (Emperor) or Khan with no special distinction between the two usages. The Kangxi Emperor also welcomed to his court Jesuit missionaries, who had first come to China under the Ming. Missionaries including Tomás Pereira, Martino Martini, Johann Adam Schall von Bell, Ferdinand Verbiest and Antoine Thomas held significant positions as military weapons experts, mathematicians, cartographers, astronomers and advisers to the emperor. The relationship of trust was however lost in the later Chinese Rites controversy.

Now answer this question: Who did the Manchu appeal to?

Output:
Mongol, Tibetan and Uighur