QUES: In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory effect as in clinical trials, however a long term study in dogs found toxic effects at higher doses and as a result mevastatin was believed to be too toxic for human use. Mevastatin was never marketed, because of its adverse effects of tumors, muscle deterioration, and sometimes death in laboratory dogs.
What was discovered in long term studies?

ANS: too toxic for human use

QUES: As a common intermediate stage, it is possible to reconstruct depalatalized affricates: *c, *dz. (This coincides with the state of affairs in the neighboring Nuristani languages.) A further complication however concerns the consonant clusters *ćw and *dźw:
What other elements of early Iranian languages problematize the east-west division?

ANS: *ćw and *dźw

QUES: In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered and developed chlorothiazide, which remains the most widely used antihypertensive drug today. This development was associated with a substantial decline in the mortality rate among people with hypertension. The inventors were recognized by a Public Health Lasker Award in 1975 for "the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension".
Why were the researchers recognized in 1975?

ANS: the saving of untold thousands of lives and the alleviation of the suffering of millions of victims of hypertension

QUES: Although spoken Tibetan varies according to the region, the written language, based on Classical Tibetan, is consistent throughout. This is probably due to the long-standing influence of the Tibetan empire, whose rule embraced (and extended at times far beyond) the present Tibetan linguistic area, which runs from northern Pakistan in the west to Yunnan and Sichuan in the east, and from north of Qinghai Lake south as far as Bhutan. The Tibetan language has its own script which it shares with Ladakhi and Dzongkha, and which is derived from the ancient Indian Brāhmī script.
What runs from northern Pakistan to Ladakhi?

ANS:
unanswerable