Input: Article: Drug discovery is the process by which potential drugs are discovered or designed. In the past most drugs have been discovered either by isolating the active ingredient from traditional remedies or by serendipitous discovery. Modern biotechnology often focuses on understanding the metabolic pathways related to a disease state or pathogen, and manipulating these pathways using molecular biology or biochemistry. A great deal of early-stage drug discovery has traditionally been carried out by universities and research institutions.

Now answer this question: Most drugs have been found by isolating what from traditional remedies?

Output: active ingredient


Article: Carnival was introduced by Portuguese settlers. The celebration is celebrated on each of the archipelago's nine inhabited islands. In Mindelo, São Vicente groups challenge each other for a yearly prize. It has imported various Brazilian carnival traditions. The celebration in SãoNicolau is more traditional, where established groups parade through the Ribeira Brava, gathering in the town square, although it has adopted drums, floats and costumes from Brazil. In São Nicolau three groups, Copa Cabana, Estrela Azul and Brilho Da Zona constructs a painted float using fire, newspaper for the mold, iron and steel to for structure. Carnival São Nicolau is celebrated over three days: dawn Saturday, Sunday afternoon, and Tuesday.

Question: Three groups in São Nicolau make use of fire in the construction of what conveyance? 
Ans: a painted float


Here is a question about this article: Worldwide use of solar power and wind power continued to grow significantly in 2012. Solar electricity consumption increased by 58 percent, to 93 terawatt-hours (TWh). Use of wind power in 2012 increased by 18.1 percent, to 521.3 TWh. Global solar and wind energy installed capacities continued to expand even though new investments in these technologies declined during 2012. Worldwide investment in solar power in 2012 was $140.4 billion, an 11 percent decline from 2011, and wind power investment was down 10.1 percent, to $80.3 billion. But due to lower production costs for both technologies, total installed capacities grew sharply. This investment decline, but growth in installed capacity, may again occur in 2013. Analysts expect the market to triple by 2030. In 2015, investment in renewables exceeded fossils.
What is the answer to this question: In 2012, solar electricity consumption increased by what percentage?
****
So... 58 percent


The problem: Answer a question about this article:
Von Neumann's team performed the world's first numerical weather forecasts on the ENIAC computer; von Neumann published the paper Numerical Integration of the Barotropic Vorticity Equation in 1950. Von Neumann's interest in weather systems and meteorological prediction led him to propose manipulating the environment by spreading colorants on the polar ice caps to enhance absorption of solar radiation (by reducing the albedo). thereby inducing global warming. Noting that the Earth was only 6 °F (3.3 °C) colder during the last glacial period, he noted that the burning of coal and oil "a general warming of the Earth by about one degree Fahrenheit."
How much colder was world in last glacial age?
****
The answer: 6 °F (3.3 °C) colder


Problem: Please answer a question about the following article about Crimean War:
It is often said that Russia was militarily weak, technologically backward, and administratively incompetent. Despite its grand ambitions toward the south, it had not built its railroad network in that direction, and communications were poor. The bureaucracy was riddled with graft, corruption and inefficiency and was unprepared for war. Its navy was weak and technologically backward; its army, although very large, was good only for parades, suffered from colonels who pocketed their men's pay, poor morale, and was out of touch with the latest technology developed by Britain and France. By the war's end, everyone realized the profound weaknesses of the Russian military, and the Russian leadership was determined to reform it.
What did Russia fail to build south?
A: railroad network


Question: Read this and answer the question

Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.

How many drugs were approved in 2007?
Answer:
18 approvals