After a period of confusion following Alexander's death, the Antigonid dynasty, descended from one of Alexander's generals, established its control over Macedon and most of the Greek city-states by 276 BC. From about 200 BC the Roman Republic became increasingly involved in Greek affairs and engaged in a series of wars with Macedon. Macedon's defeat at the Battle of Pydna in 168 BC signalled the end of Antigonid power in Greece. In 146 BC Macedonia was annexed as a province by Rome, and the rest of Greece became a Roman protectorate.

Who controlled Macedon after Alexander died?