This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

Input: Consider Input: TB infection begins when the mycobacteria reach the pulmonary alveoli, where they invade and replicate within endosomes of alveolar macrophages. Macrophages identify the bacterium as foreign and attempt to eliminate it by phagocytosis. During this process, the bacterium is enveloped by the macrophage and stored temporarily in a membrane-bound vesicle called a phagosome. The phagosome then combines with a lysosome to create a phagolysosome. In the phagolysosome, the cell attempts to use reactive oxygen species and acid to kill the bacterium. However, M. tuberculosis has a thick, waxy mycolic acid capsule that protects it from these toxic substances. M. tuberculosis is able to reproduce inside the macrophage and will eventually kill the immune cell.

Output: What specific part of the lungs marks the start of tuberculosis infection?


Input: Consider Input: There are several reasons an otherwise valid and agreed upon treaty may be rejected as a binding international agreement, most of which involve problems created at the formation of the treaty.[citation needed] For example, the serial Japan-Korea treaties of 1905, 1907 and 1910 were protested; and they were confirmed as "already null and void" in the 1965 Treaty on Basic Relations between Japan and the Republic of Korea.

Output: When are most of the problems created that might result in an otherwise valid treaty being rejected as a binding international agreement?


Input: Consider Input: To the north, the Sahara skirts the Mediterranean Sea in Egypt and portions of Libya, but in Cyrenaica and the Maghreb, the Sahara borders the Mediterranean forest, woodland, and scrub ecoregions of northern Africa, all of which have a Mediterranean climate characterized by hot summers and cool and rainy winters. According to the botanical criteria of Frank White and geographer Robert Capot-Rey, the northern limit of the Sahara corresponds to the northern limit of date palm cultivation and the southern limit of the range of esparto, a grass typical of the Mediterranean climate portion of the Maghreb and Iberia. The northern limit also corresponds to the 100 mm (3.9 in) isohyet of annual precipitation.
Output: What sea is North of the Sahara Desert?