Problem: Florey and Chain succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was determined by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. The discovery of such a powerful antibiotic was unprecedented, and the development of penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Ernst Chain and Howard Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.
When was the chemical make-up of penicillin discovered?
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Answer: 1945


Problem: Von Neumann's abstract treatment permitted him also to confront the foundational issue of determinism versus non-determinism, and in the book he presented a proof that the statistical results of quantum mechanics could not possibly be averages of an underlying set of determined "hidden variables," as in classical statistical mechanics. In 1966, John S. Bell published a paper arguing that the proof contained a conceptual error and was therefore invalid. However, in 2010, Jeffrey Bub argued that Bell had misconstrued von Neumann's proof, and pointed out that the proof, though not valid for all hidden variable theories, does rule out a well-defined and important subset. Bub also suggests that von Neumann was aware of this limitation, and that von Neumann did not claim that his proof completely ruled out hidden variable theories.
What did Jeffrey Bub argue in 2010?
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Answer: Bell had misconstrued von Neumann's proof


Problem: Valleys and plains are found along the coastline and rivers. The north of the province lies just south of the Yangtze Delta, and consists of plains around the cities of Hangzhou, Jiaxing, and Huzhou, where the Grand Canal of China enters from the northern border to end at Hangzhou. Another relatively flat area is found along the Qu River around the cities of Quzhou and Jinhua. Major rivers include the Qiangtang and Ou Rivers. Most rivers carve out valleys in the highlands, with plenty of rapids and other features associated with such topography. Well-known lakes include the West Lake of Hangzhou and the South Lake of Jiaxing.
Where does the Grand Canal of China end?
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Answer:
Hangzhou