In the U.S., a push for revisions of the FD&C Act emerged from Congressional hearings led by Senator Estes Kefauver of Tennessee in 1959. The hearings covered a wide range of policy issues, including advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry. While momentum for new legislation temporarily flagged under extended debate, a new tragedy emerged that underscored the need for more comprehensive regulation and provided the driving force for the passage of new laws.
What caused a need for more regulation?
a new tragedy emerged

The prognosis for asthma is generally good, especially for children with mild disease. Mortality has decreased over the last few decades due to better recognition and improvement in care. Globally it causes moderate or severe disability in 19.4 million people as of 2004 (16 million of which are in low and middle income countries). Of asthma diagnosed during childhood, half of cases will no longer carry the diagnosis after a decade. Airway remodeling is observed, but it is unknown whether these represent harmful or beneficial changes. Early treatment with corticosteroids seems to prevent or ameliorates a decline in lung function.
What has caused the mortality rate to decrease?
due to better recognition and improvement in care

The Umayyad Caliphate (Arabic: الخلافة الأموية‎, trans. Al-Khilāfat al-ʾumawiyya) was the second of the four major Islamic caliphates established after the death of Muhammad. This caliphate was centered on the Umayyad dynasty (Arabic: الأمويون‎, al-ʾUmawiyyūn, or بنو أمية, Banū ʾUmayya, "Sons of Umayya"), hailing from Mecca. The Umayyad family had first come to power under the third caliph, Uthman ibn Affan (r. 644–656), but the Umayyad regime was founded by Muawiya ibn Abi Sufyan, long-time governor of Syria, after the end of the First Muslim Civil War in 661 CE/41 AH. Syria remained the Umayyads' main power base thereafter, and Damascus was their capital. The Umayyads continued the Muslim conquests, incorporating the Caucasus, Transoxiana, Sindh, the Maghreb and the Iberian Peninsula (Al-Andalus) into the Muslim world. At its greatest extent, the Umayyad Caliphate covered 15 million km2 (5.79 million square miles), making it the largest empire (in terms of area - not in terms of population) the world had yet seen, and the fifth largest ever to exist.
How many million square miles was the Umayyad caliphate at its largest size?
5.79