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Following the Fall of Constantinople on 29 May 1453, many Greeks sought better employment and education opportunities by leaving for the West, particularly Italy, Central Europe, Germany and Russia. Greeks are greatly credited for the European cultural revolution, later called, the Renaissance. In Greek-inhabited territory itself, Greeks came to play a leading role in the Ottoman Empire, due in part to the fact that the central hub of the empire, politically, culturally, and socially, was based on Western Thrace and Greek Macedonia, both in Northern Greece, and of course was centred on the mainly Greek-populated, former Byzantine capital, Constantinople. As a direct consequence of this situation, Greek-speakers came to play a hugely important role in the Ottoman trading and diplomatic establishment, as well as in the church. Added to this, in the first half of the Ottoman period men of Greek origin made up a significant proportion of the Ottoman army, navy, and state bureaucracy, having been levied as adolescents (along with especially Albanians and Serbs) into Ottoman service through the devshirme. Many Ottomans of Greek (or Albanian or Serb) origin were therefore to be found within the Ottoman forces which governed the provinces, from Ottoman Egypt, to Ottomans occupied Yemen and Algeria, frequently as provincial governors.

When did the emperor Constantine  lose rule over in 1453 ?
Fall of Constantinople on 29 May 1453