Input: Read this: Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molecular Entities) were approved and three biologics by the FDA, or 21 in total, which is down from 26 in 2009 and 24 in 2008. On the other hand, there were only 18 approvals in total in 2007 and 22 back in 2006. Since 2001, the Center for Drug Evaluation and Research has averaged 22.9 approvals a year. This approval comes only after heavy investment in pre-clinical development and clinical trials, as well as a commitment to ongoing safety monitoring. Drugs which fail part-way through this process often incur large costs, while generating no revenue in return. If the cost of these failed drugs is taken into account, the cost of developing a successful new drug (new chemical entity, or NCE), has been estimated at about 1.3 billion USD(not including marketing expenses). Professors Light and Lexchin reported in 2012, however, that the rate of approval for new drugs has been a relatively stable average rate of 15 to 25 for decades.
Question: How much does it cost to develop approvals?

Output: unanswerable


QUES: The Ming dynasty granted titles to lamas of schools such as the Karmapa Kargyu, but the latter had previously declined Mongol invitations to receive titles. When the Ming Yongle Emperor invited Je Tsongkhapa (1357–1419), founder of the Gelug school, to come to the Ming court and pay tribute, the latter declined. Wang and Nyima write that this was due to old age and physical weakness, and also because of efforts being made to build three major monasteries. Chen Qingying states that Tsongkhapa wrote a letter to decline the Emperor's invitation, and in this reply, Tsongkhapa wrote:

Who wrote the letter declining the Emperor's invitation?
What is the answer?
ANS: Tsongkhapa


QUES: Although many of FBI's functions are unique, its activities in support of national security are comparable to those of the British MI5 and the Russian FSB. Unlike the Central Intelligence Agency (CIA), which has no law enforcement authority and is focused on intelligence collection overseas, FBI is primarily a domestic agency, maintaining 56 field offices in major cities throughout the United States, and more than 400 resident agencies in lesser cities and areas across the nation. At an FBI field office, a senior-level FBI officer concurrently serves as the representative of the Director of National Intelligence.
How many field offices does the CIA have in major cities in the United States?

ANS: unanswerable


The 2009 Human Development Report by UNDP was released on October 5, 2009, and covers the period up to 2007. It was titled "Overcoming barriers: Human mobility and development". The top countries by HDI were grouped in a new category called "very high human development". The report refers to these countries as developed countries. They are:
If it is possible to answer this question, answer it for me (else, reply "unanswerable"): On what date was the 2009 Human Development Report released?
Ah, so.. October 5, 2009


Question: Following the 11 September 2001 attacks, former President of Pakistan Pervez Musharraf sided with the U.S. against the Taliban government in Afghanistan after an ultimatum by then U.S. President George W. Bush. Musharraf agreed to give the U.S. the use of three airbases for Operation Enduring Freedom. United States Secretary of State Colin Powell and other U.S. administration officials met with Musharraf. On 19 September 2001, Musharraf addressed the people of Pakistan and stated that, while he opposed military tactics against the Taliban, Pakistan risked being endangered by an alliance of India and the U.S. if it did not cooperate. In 2006, Musharraf testified that this stance was pressured by threats from the U.S., and revealed in his memoirs that he had "war-gamed" the United States as an adversary and decided that it would end in a loss for Pakistan.
Try to answer this question if possible: Which former president sided with the Taliban?
Answer: unanswerable


Problem: In the late renaissance various writers began to question the medieval and classical understanding of knowledge acquisition in a more fundamental way. In political and historical writing Niccolò Machiavelli and his friend Francesco Guicciardini initiated a new realistic style of writing. Machiavelli in particular was scornful of writers on politics who judged everything in comparison to mental ideals and demanded that people should study the "effectual truth" instead. Their contemporary, Leonardo da Vinci (1452–1519) said, "If you find from your own experience that something is a fact and it contradicts what some authority has written down, then you must abandon the authority and base your reasoning on your own findings."
Who did Machiavelli disdain?
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Answer:
writers on politics who judged everything in comparison to mental ideals