Problem: Most mutations within genes are neutral, having no effect on the organism's phenotype (silent mutations). Some mutations do not change the amino acid sequence because multiple codons encode the same amino acid (synonymous mutations). Other mutations can be neutral if they lead to amino acid sequence changes, but the protein still functions similarly with the new amino acid (e.g. conservative mutations). Many mutations, however, are deleterious or even lethal, and are removed from populations by natural selection. Genetic disorders are the result of deleterious mutations and can be due to spontaneous mutation in the affected individual, or can be inherited. Finally, a small fraction of mutations are beneficial, improving the organism's fitness and are extremely important for evolution, since their directional selection leads to adaptive evolution.:7.6
What are mutations that lead to amino acid sequence changes but leave the protein functioning similarly called?
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Answer: conservative mutations


Problem: In 1790, the first federal population census was taken in the United States. Enumerators were instructed to classify free residents as white or "other." Only the heads of households were identified by name in the federal census until 1850. Native Americans were included among "Other;" in later censuses, they were included as "Free people of color" if they were not living on Indian reservations. Slaves were counted separately from free persons in all the censuses until the Civil War and end of slavery. In later censuses, people of African descent were classified by appearance as mulatto (which recognized visible European ancestry in addition to African) or black.
What year was the last federal population census taken in the United States?
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Answer: unanswerable


Problem: The Gurkhas, a martial tribe, came to power in Nepal in the year 1768. They consolidated their military power and began to expand their territory. Gradually, the Gorkhas annexed Sirmour and Shimla. With the leadership of Amar Singh Thapa, Gorkhas laid siege to Kangra. They managed to defeat Sansar Chand Katoch, the ruler of Kangra, in 1806 with the help of many provincial chiefs. However, Gurkhas could not capture Kangra fort which came under Maharaja Ranjeet Singh in 1809. After the defeat, the Gurkhas began to expand towards the south of the state. However, Raja Ram Singh, Raja of Siba State managed to capture the fort of Siba from the remnants of Lahore Darbar in Samvat 1846, during the First Anglo-Sikh War. They came into direct conflict with the British along the tarai belt after which the British expelled them from the provinces of the Satluj. The British gradually emerged as the paramount power. In the revolt of 1857, or first Indian war of independence, arising from a number of grievances against the British, the people of the hill states were not as politically active as were those in other parts of the country. They and their rulers, with the exception of Bushahr, remained more or less inactive. Some, including the rulers of Chamba, Bilaspur, Bhagal and Dhami, rendered help to the British government during the revolt.
In what year did Kangra come to power in Nepal?
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Answer:
unanswerable