This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

Example Input: Wound colonization refers to nonreplicating microorganisms within the wound, while in infected wounds, replicating organisms exist and tissue is injured. All multicellular organisms are colonized to some degree by extrinsic organisms, and the vast majority of these exist in either a mutualistic or commensal relationship with the host. An example of the former is the anaerobic bacteria species, which colonizes the mammalian colon, and an example of the latter is various species of staphylococcus that exist on human skin. Neither of these colonizations are considered infections. The difference between an infection and a colonization is often only a matter of circumstance. Non-pathogenic organisms can become pathogenic given specific conditions, and even the most virulent organism requires certain circumstances to cause a compromising infection. Some colonizing bacteria, such as Corynebacteria sp. and viridans streptococci, prevent the adhesion and colonization of pathogenic bacteria and thus have a symbiotic relationship with the host, preventing infection and speeding wound healing.
Example Output: What does wound colonization refer to?

Example Input: Prior to the Golden Age of Mandolins, France had a history with the mandolin, with mandolinists playing in Paris until the Napoleonic Wars. The players, teachers and composers included Giovanni Fouchetti, Eduardo Mezzacapo, Gabriele Leon, and Gervasio. During the Golden age itself (1880s-1920s), the mandolin had a strong presence in France. Prominent mandolin players or composers included Jules Cottin and his sister Madeleine Cottin, Jean Pietrapertosa, and Edgar Bara. Paris had dozens of "estudiantina" mandolin orchestras in the early 1900s. Mandolin magazines included L'Estudiantina, Le Plectre, École de la mandolie.
Example Output: Prior to what age did France have a history with the mandolin?

Example Input: On November 2, 2014, the Cubs announced that Joe Maddon had signed a five-year contract to be the 54th manager in team history. On December 10, 2014, Maddon announced that the team had signed free agent Jon Lester to a 6-year, $155 million contract. Many other trades and acquisitions occurred during the off season. The opening day lineup for the Cubs contained five new players including rookie right fielder Jorge Soler. Rookies Kris Bryant and Addison Russell were in the starting lineup by mid-April, and rookie Kyle Schwarber was added in mid-June. The Cubs finished the 2015 season with a record of 97–65, third best in the majors. On October 7, in the 2015 National League Wild Card Game, Jake Arrieta pitched a complete game shutout and the Cubs defeated the Pittsburgh Pirates 4–0.
Example Output:
When did the Cubs announce that Joe Maddon had signed a five-year contract to be the 54th manager?