Context and question: Several lines of evidence indicate lifestyle-induced hyperinsulinemia and reduced insulin function (i.e., insulin resistance) as a decisive factor in many disease states. For example, hyperinsulinemia and insulin resistance are strongly linked to chronic inflammation, which in turn is strongly linked to a variety of adverse developments such as arterial microinjuries and clot formation (i.e., heart disease) and exaggerated cell division (i.e., cancer). Hyperinsulinemia and insulin resistance (the so-called metabolic syndrome) are characterized by a combination of abdominal obesity, elevated blood sugar, elevated blood pressure, elevated blood triglycerides, and reduced HDL cholesterol. The negative impact of hyperinsulinemia on prostaglandin PGE1/PGE2 balance may be significant.
Hyperinsulinemia has a negative effect on the levels of which important molecules in the body?
Answer: prostaglandin PGE1/PGE2
Context and question: Studies by Nathaniel Kleitman in 1938 and by Derk-Jan Dijk and Charles Czeisler in the 1990s put human subjects on enforced 28-hour sleep–wake cycles, in constant dim light and with other time cues suppressed, for over a month. Because normal people cannot entrain to a 28-hour day in dim light if at all,[citation needed] this is referred to as a forced desynchrony protocol. Sleep and wake episodes are uncoupled from the endogenous circadian period of about 24.18 hours and researchers are allowed to assess the effects of circadian phase on aspects of sleep and wakefulness including sleep latency and other functions.[page needed]
How long did the suppression of time clues study last?
Answer: month
Context and question: Some established acts continued to enjoy commercial success, such as Aerosmith, with their number one multi-platinum albums: Get a Grip (1993), which produced four Top 40 singles and became the band's best-selling album worldwide (going on to sell over 10 million copies), and Nine Lives (1997). In 1998, Aerosmith released the number one hit "I Don't Want to Miss a Thing", which remains the only single by a hard rock band to debut at number one. AC/DC produced the double platinum Ballbreaker (1995). Bon Jovi appealed to their hard rock audience with songs such as "Keep the Faith" (1992), but also achieved success in adult contemporary radio, with the Top 10 ballads "Bed of Roses" (1993) and "Always" (1994). Bon Jovi's 1995 album These Days was a bigger hit in Europe than it was in the United States, spawning four Top 10 singles on the UK Singles Chart. Metallica's Load (1996) and ReLoad (1997) each sold in excess of 4 million copies in the US and saw the band develop a more melodic and blues rock sound. As the initial impetus of grunge bands faltered in the middle years of the decade, post-grunge bands emerged. They emulated the attitudes and music of grunge, particularly thick, distorted guitars, but with a more radio-friendly commercially oriented sound that drew more directly on traditional hard rock. Among the most successful acts were the Foo Fighters, Candlebox, Live, Collective Soul, Australia's Silverchair and England's Bush, who all cemented post-grunge as one of the most commercially viable subgenres by the late 1990s. Similarly, some post-Britpop bands that followed in the wake of Oasis, including Feeder and Stereophonics, adopted a hard rock or "pop-metal" sound.
When did AC/DC release their number one hit I don't Want to Miss a Thing?
Answer:
unanswerable