Input: Gene
Housekeeping genes are critical for carrying out basic cell functions and so are expressed at a relatively constant level (constitutively). Since their expression is constant, housekeeping genes are used as experimental controls when analysing gene expression. Not all essential genes are housekeeping genes since some essential genes are developmentally regulated or expressed at certain times during the organism's life cycle.

How are some essential genes regulated?
Output: developmentally

Input: Nanjing
The radish is also a typical food representing people of Nanjing, which has been spread through word of mouth as an interesting fact for many years in China. According to Nanjing.GOV.cn, "There is a long history of growing radish in Nanjing especially the southern suburb. In the spring, the radish tastes very juicy and sweet. It is well-known that people in Nanjing like eating radish. And the people are even addressed as 'Nanjing big radish', which means they are unsophisticated, passionate and conservative. From health perspective, eating radish can help to offset the stodgy food that people take during the Spring Festival".

What are Nanjing people called by others?
Output: 'Nanjing big radish'

Input: The Legend of Zelda: Twilight Princess
During this time, Link also helps Midna find the Fused Shadows, fragments of a relic containing powerful dark magic. In return, she helps Link find Ordon Village's children while helping the monkeys of Faron, the Gorons of Eldin, and the Zoras of Lanayru. Once Link has restored the Light Spirits and Midna has all the Fused Shadows, they are ambushed by Zant. After he relieves Midna of the Fused Shadow fragments, she ridicules him for abusing his tribe's magic, but Zant reveals that his power comes from another source as he uses it to turn Link back into a wolf, and then leaves Midna in Hyrule to die from the world's light. Bringing a dying Midna to Zelda, Link learns he needs the Master Sword to return to human form. Zelda sacrifices herself to heal Midna with her power before vanishing mysteriously. Midna is moved by Zelda's sacrifice, and begins to care more about Link and the fate of the light world.

Who attacks Link and Midna when they've finished their collection tasks?
Output: Zant

Input: St. John%27s, Newfoundland and Labrador
St. John's is one of the oldest settlements in North America, with year-round settlement beginning sometime after 1630 and seasonal habitation long before that. It is not, however, the oldest surviving English settlement in North America or Canada, having been preceded by the Cuper's Cove colony at Cupids, founded in 1610, and the Bristol's Hope colony at Harbour Grace, founded in 1618. In fact, although English fishermen had begun setting up seasonal camps in Newfoundland in the 16th Century, they were expressly forbidden by the British government, at the urging of the West Country fishing industry, from establishing permanent settlements along the English controlled coast, hence the town of St. John's was not established as a permanent community until after the 1630s at the earliest. Other permanent English settlements in the Americas that predate St. John's include: St. George's, Bermuda (1612) and Jamestown, Virginia (1607).

Around what year did settlement begin to occur in St. John's?
Output:
1630