Problem: Pain:

In 1644, René Descartes theorized that pain was a disturbance that passed down along nerve fibers until the disturbance reached the brain, a development that transformed the perception of pain from a spiritual, mystical experience to a physical, mechanical sensation[citation needed]. Descartes's work, along with Avicenna's, prefigured the 19th-century development of specificity theory. Specificity theory saw pain as "a specific sensation, with its own sensory apparatus independent of touch and other senses". Another theory that came to prominence in the 18th and 19th centuries was intensive theory, which conceived of pain not as a unique sensory modality, but an emotional state produced by stronger than normal stimuli such as intense light, pressure or temperature. By the mid-1890s, specificity was backed mostly by physiologists and physicians, and the intensive theory was mostly backed by psychologists. However, after a series of clinical observations by Henry Head and experiments by Max von Frey, the psychologists migrated to specificity almost en masse, and by century's end, most textbooks on physiology and psychology were presenting pain specificity as fact.

What did Henry von Frey and Max Head make?
---
A: unanswerable


Problem: Alsace:

From the annexation of Alsace by France in the 17th century and the language policy of the French Revolution up to 1870, knowledge of French in Alsace increased considerably. With the education reforms of the 19th century, the middle classes began to speak and write French well. The French language never really managed, however, to win over the masses, the vast majority of whom continued to speak their German dialects and write in German (which we would now call "standard German").[citation needed]

Standard Germany became policy during what revolution?
---
A: unanswerable


Problem: Christian:

The first recorded use of the term (or its cognates in other languages) is in the New Testament, in Acts 11:26, after Barnabas brought Saul (Paul) to Antioch where they taught the disciples for about a year, the text says: "[...] the disciples were called Christians first in Antioch." The second mention of the term follows in Acts 26:28, where Herod Agrippa II replied to Paul the Apostle, "Then Agrippa said unto Paul, Almost thou persuadest me to be a Christian." The third and final New Testament reference to the term is in 1 Peter 4:16, which exhorts believers: "Yet if [any man suffer] as a Christian, let him not be ashamed; but let him glorify God on this behalf."

In which book of the old testament is the first known usage of the term?
---
A: unanswerable


Problem: Bacteria:

Gram-positive bacteria possess a thick cell wall containing many layers of peptidoglycan and teichoic acids. In contrast, gram-negative bacteria have a relatively thin cell wall consisting of a few layers of peptidoglycan surrounded by a second lipid membrane containing lipopolysaccharides and lipoproteins. Lipopolysaccharides, also called endotoxins, are composed of polysaccharides and lipid A that is responsible for much of the toxicity of gram-negative bacteria. Most bacteria have the gram-negative cell wall, and only the Firmicutes and Actinobacteria have the alternative gram-positive arrangement. These two groups were previously known as the low G+C and high G+C Gram-positive bacteria, respectively. These differences in structure can produce differences in antibiotic susceptibility; for instance, vancomycin can kill only gram-positive bacteria and is ineffective against gram-negative pathogens, such as Haemophilus influenzae or Pseudomonas aeruginosa. If the bacterial cell wall is entirely removed, it is called a protoplast, whereas if it is partially removed, it is called a spheroplast. β-Lactam antibiotics, such as penicillin, inhibit the formation of peptidoglycan cross-links in the bacterial cell wall. The enzyme lysozyme, found in human tears, also digests the cell wall of bacteria and is the body's main defense against eye infections.

What can be endotoxins called?
---
A:
Lipopolysaccharides