Context and question: Melatonin is absent from the system or undetectably low during daytime. Its onset in dim light, dim-light melatonin onset (DLMO), at roughly 21:00 (9 p.m.) can be measured in the blood or the saliva. Its major metabolite can also be measured in morning urine. Both DLMO and the midpoint (in time) of the presence of the hormone in the blood or saliva have been used as circadian markers. However, newer research indicates that the melatonin offset may be the more reliable marker. Benloucif et al. found that melatonin phase markers were more stable and more highly correlated with the timing of sleep than the core temperature minimum. They found that both sleep offset and melatonin offset are more strongly correlated with phase markers than the onset of sleep. In addition, the declining phase of the melatonin levels is more reliable and stable than the termination of melatonin synthesis.
When is the melatonin onset?
Answer: 9 p.m
Context and question: President Franklin Roosevelt ordered General Douglas MacArthur in the Philippines to formulate a Pacific defence plan with Australia in March 1942. Curtin agreed to place Australian forces under the command of MacArthur who became Supreme Commander, South West Pacific. MacArthur moved his headquarters to Melbourne in March 1942 and American troops began massing in Australia. Enemy naval activity reached Sydney in late May 1942, when Japanese midget submarines launched a daring raid on Sydney Harbour. On 8 June 1942, two Japanese submarines briefly shelled Sydney's eastern suburbs and the city of Newcastle.
When was General MacArthur ordered to make a defense plan with Australia?
Answer: March 1942
Context and question: On 23 October 1501, at Mielnik Polish–Lithuanian union was reformed at the Union of Mielnik (Polish: unia mielnicka, unia piotrkowsko-mielnicka). It was there that the tradition of the coronation Sejm (Polish: "Sejm koronacyjny") was founded. Once again the middle nobility (middle in wealth, not in rank) attempted to reduce the power of the magnates with a law that made them impeachable before the Senate for malfeasance. However the Act of Mielno (Polish: Przywilej mielnicki) of 25 October did more to strengthen the magnate dominated Senate of Poland then the lesser nobility. The nobles were given the right to disobey the King or his representatives—in the Latin, "non praestanda oboedientia"—and to form confederations, an armed rebellion against the king or state officers if the nobles thought that the law or their legitimate privileges were being infringed.
Where was the Mielnik Polish–Lithuanian union refromed?
Answer:
Union of Mielnik