In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approval, three phases of progressively larger human clinical trials may be conducted. Phase I generally studies toxicity using healthy volunteers. Phase II can include pharmacokinetics and dosing in patients, and Phase III is a very large study of efficacy in the intended patient population. Following the successful completion of phase III testing, a New Drug Application is submitted to the FDA. The FDA review the data and if the product is seen as having a positive benefit-risk assessment, approval to market the product in the US is granted.
What type of risk assessment results in approving the drug to go on the market?
positive benefit-risk

John was incensed about what he perceived as an abrogation of his customary right as monarch to influence the election. He complained both about the choice of Langton as an individual, as John felt he was overly influenced by the Capetian court in Paris, and about the process as a whole. He barred Langton from entering England and seized the lands of the archbishopric and other papal possessions. Innocent set a commission in place to try to convince John to change his mind, but to no avail. Innocent then placed an interdict on England in March 1208, prohibiting clergy from conducting religious services, with the exception of baptisms for the young, and confessions and absolutions for the dying.
John felt Langton was overly influenced by what?
the Capetian court in Paris

At the start of her reign Victoria was popular, but her reputation suffered in an 1839 court intrigue when one of her mother's ladies-in-waiting, Lady Flora Hastings, developed an abdominal growth that was widely rumoured to be an out-of-wedlock pregnancy by Sir John Conroy. Victoria believed the rumours. She hated Conroy, and despised "that odious Lady Flora", because she had conspired with Conroy and the Duchess of Kent in the Kensington System. At first, Lady Flora refused to submit to a naked medical examination, until in mid-February she eventually agreed, and was found to be a virgin. Conroy, the Hastings family and the opposition Tories organised a press campaign implicating the Queen in the spreading of false rumours about Lady Flora. When Lady Flora died in July, the post-mortem revealed a large tumour on her liver that had distended her abdomen. At public appearances, Victoria was hissed and jeered as "Mrs. Melbourne".
What did Victoria think of Lady Flora?
despised