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This task is about reading the given passage and construct a question about the information present in the passage. Construct a question in such a way that (i) it is unambiguous, (ii) it is answerable from the passage, (iii) its answer is unique (iv) its answer is a continuous text span from the paragraph. Avoid creating questions that (i) can be answered correctly without actually understanding the paragraph and (ii) uses same words or phrases given in the passage.

In the centre of Basel, the first major city in the course of the stream, is located the "Rhine knee"; this is a major bend, where the overall direction of the Rhine changes from West to North. Here the High Rhine ends. Legally, the Central Bridge is the boundary between High and Upper Rhine. The river now flows North as Upper Rhine through the Upper Rhine Plain, which is about 300 km long and up to 40 km wide. The most important tributaries in this area are the Ill below of Strasbourg, the Neckar in Mannheim and the Main across from Mainz. In Mainz, the Rhine leaves the Upper Rhine Valley and flows through the Mainz Basin.
Output:
What is the first major city in the stream of the Rhine?